LncRNA SNHG3 promotes cell proliferation and invasion through the miR-384/hepatoma-derived growth factor axis in breast cancer
LncRNA SNHG3 promotes cell proliferation and invasion through the miR-384/hepatoma-derived growth factor axis in breast cancer
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DOI：
10.1007/s13577-019-00287-9
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发表时间：
2019-10-04
期刊：
影响因子：
4.3
通讯作者：
Hu, Wei
中科院分区：
文献类型：
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作者：
Ma, Qiuhong;Qi, Xiangqin;Hu, Wei
长链非编码RNA （lncRNAs）已被发现在癌症中异常表达，而lncRNA小核果RNA宿主基因（snhg）在肿瘤进展中起着关键作用。SNHG3已被确定为多种肿瘤类型的致癌基因。然而，SNHG3在乳腺癌中的作用尚未见报道。在本研究中，我们发现SNHG3在乳腺癌患者中表达上调并与肿瘤恶性相关。在体外和体内实验中，敲低SNHG3抑制乳腺癌细胞的生长和转移能力。我们使用生物信息学预测和功能分析验证来确定SNHG3上调抑制miR-384活性并导致乳腺癌细胞中肝癌源性生长因子（HDGF）过表达。本研究结果表明，SNHG3在乳腺癌中发挥致癌基因的作用，通过调控miR-384/HDGF轴促进乳腺癌细胞的增殖和侵袭。本研究可能为乳腺癌的治疗提供新的靶点。
Long noncoding RNAs (lncRNAs) have been found to be abnormally expressed in cancer, and lncRNA small nucleolar RNA host genes (SNHGs) play critical roles in tumour progression. SNHG3 has been identified as an oncogene in multiple tumour types. However, the role of SNHG3 in breast cancer has not been reported. In this study, we found that SNHG3 was upregulated and associated with tumour malignancy in patients with breast cancer. SNHG3 knockdown inhibited the growth and metastatic capabilities of breast cancer cells in vitro and vivo. We used bioinformatics prediction and functional assay validation to determine that SNHG3 upregulation inhibited miR-384 activity and led to hepatoma-derived growth factor (HDGF) overexpression in breast cancer cells. The findings of this study show that SNHG3 functions as an oncogene in breast cancer and promotes breast cancer cell proliferation and invasion by regulating the miR-384/HDGF axis. The present study might provide a new target for the treatment of breast cancer.