Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.
Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.
复制标题
海马内给予秋水仙碱对激励对比和径向迷宫表现的影响。
DOI：
10.1037//0735-7044.103.2.319
复制
发表时间：
1989
影响因子：
1.9
通讯作者：
Walsh,TJ
中科院分区：
文献类型：
--
作者：
Flaherty,CF;Rowan,GA;Emerich,DF;Walsh,TJ
在三个实验环境中，对接受神经毒素秋水仙碱齿状体内注射的大鼠的行为进行了检测。在实验1中，秋水仙碱处理组、人工脑脊液处理组和未处理组动物对32%和4%蔗糖溶液的摄入量没有差异，当32%蔗糖溶液改为4%蔗糖溶液时，它们的连续阴性对照程度也没有差异。在实验2中，秋水仙碱治疗和脑脊液治疗的动物在每天一次的配对中，当0.15%的糖精溶液先于32%的蔗糖摄入时，其抑制程度没有差异(预见性对照)，当糖精-蔗糖和糖精-糖精配对颠倒时，它们的逆转表现也没有差异。在实验3中，与脑脊液治疗的对照组相比，秋水仙碱治疗的动物在放射臂迷宫中的表现明显受损。这些结果表明，完全正常的海马体对于奖赏质量的记忆、奖赏的比较、奖赏减少时的行为抑制、两个奖赏水平之间的联系的形成以及这种联系的逆转并不是必需的，只要这些过程反映在消费行为中。这些数据是根据仪器行为和感觉记忆和/或消耗性行为之间的差异来解释的-这种解释与受损动物的工作记忆缺陷并不矛盾。
The behavior of rats given intradentate injections of the neurotoxin colchicine was examined in three experimental settings. In Experiment 1, colchicine-treated, artificial cerebrospinal fluid (CSF)-treated, and untreated animals did not differ in the intake of 32% and 4% sucrose solutions, nor did they differ in degree of successive negative contrast when the 32% solution was changed to 4% sucrose. In Experiment 2, the colchicine-treated and CSF-treated animals did not differ in degree of suppression in the intake of a 0.15% saccharin solution when it preceded 32% sucrose in once-daily pairings (anticipatory contrast), nor did they differ in reversal performance when saccharin–sucrose and saccharin–saccharin pairings were reversed. In Experiment 3, the colchicine-treated animals were substantially impaired in radial-arm maze performance compared with CSF-treated controls. These results suggest that a completely functioning hippocampus is not necessary for the memory of reward quality, the comparison of rewards, the suppression of behavior when reward is decreased, the formation of associations between two levels of reward, and the reversal of this association, as long as these processes are reflected in consummatory behavior. The data are interpreted in terms of differences between instrumental behavior and sensory memory and/or consummatory behavior—an interpretation that is not incompatible with a deficiency in working memory in the animals with lesions.
动物行为的认知过程
DOI：
--
发表时间：
1979
期刊：
影响因子：
--
作者：
S. H. Hulse;H. Fowler;W. K. Honig
通讯作者：
W. K. Honig
抑制与学习
影响因子：
1.3
作者：
P. Frey;R. Boakes;M. Halliday
通讯作者：
M. Halliday