Clustered protocadherins
Clustered protocadherins
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DOI：
10.1242/dev.090621
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发表时间：
2013-08-15
期刊：
影响因子：
4.6
通讯作者：
Maniatis, Tom
中科院分区：
文献类型：
--
作者：
Chen, Weisheng V.;Maniatis, Tom
大多数脊椎动物原钙粘蛋白（Pcdh）基因聚集在一个基因组位点上，这种显著的基因组组织从硬骨鱼到人类都是高度保守的。这些聚集的Pcdhs在单个神经元中有不同的表达，它们作为多聚体参与亲同性的反式相互作用，并且它们是多种神经发育过程所必需的，包括神经突自我回避。在这里，我们简要概述了聚类Pcdhs的分子和细胞生物学，强调了它们如何在脊椎动物神经系统中产生单细胞多样性，以及这种多样性如何用于神经回路组装。
The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single genomic locus, and this remarkable genomic organization is highly conserved from teleosts to humans. These clustered Pcdhs are differentially expressed in individual neurons, they engage in homophilic trans-interactions as multimers and they are required for diverse neurodevelopmental processes, including neurite self-avoidance. Here, we provide a concise overview of the molecular and cellular biology of clustered Pcdhs, highlighting how they generate single cell diversity in the vertebrate nervous system and how such diversity may be used in neural circuit assembly.