A Review of the Novel Application and Potential Adverse Effects of Proton Pump Inhibitors.
A Review of the Novel Application and Potential Adverse Effects of Proton Pump Inhibitors.
复制标题
质子泵抑制剂的新颖应用和潜在不利影响的综述。
DOI：
10.1007/s12325-017-0532-9
复制
发表时间：
2017-05
影响因子：
3.8
通讯作者：
Wang YQ
中科院分区：
文献类型：
--
作者：
Yu LY;Sun LN;Zhang XH;Li YQ;Yu L;Yuan ZQ;Meng L;Zhang HW;Wang YQ
质子泵抑制剂（PPIs）是一类以胃壁细胞中的H+/K+- atp酶为靶点的药物。PPIs广泛应用于胃酸相关疾病的治疗，包括消化性溃疡病、糜烂性食管炎、胃食管反流病等。这些药物具有良好的安全性，已成为初级和专科护理中最常用的处方药之一。PPIs除用于胃酸相关疾病外，还可用于治疗幽门螺杆菌感染、病毒感染、呼吸系统疾病、癌症等。虽然PPIs主要用于消化性溃疡患者的短期治疗，但如今这些药物越来越多地用于长期治疗，并且经常用于终身治疗，例如用于具有典型或非典型胃食管反流疾病症状的患者，以及有胃毒性和出血、穿孔和胃出口梗阻等相关并发症风险的非甾体抗炎药或阿司匹林使用者。长期使用PPIs可能导致潜在的不良反应，如骨质疏松性骨折、肾损害、感染（肺炎和艰难梭菌感染）、横纹肌溶解、营养缺乏（维生素B12、镁和铁）、贫血和血小板减少症。在本文中，我们将回顾PPIs在其他领域的一些新用途，并总结潜在的不良反应。
Proton pump inhibitors (PPIs) are known as a class of pharmaceutical agents that target H+/K+-ATPase, which is located in gastric parietal cells. PPIs are widely used in the treatment of gastric acid-related diseases including peptic ulcer disease, erosive esophagitis and gastroesophageal reflux disease, and so on. These drugs present an excellent safety profile and have become one of the most commonly prescribed drugs in primary and specialty care. Except for gastric acid-related diseases, PPIs can also be used in the treatment of Helicobacter pylori infection, viral infections, respiratory system diseases, cancer and so on. Although PPIs are mainly used short term in patients with peptic ulcer disease, nowadays these drugs are increasingly used long term, and frequently for a lifetime, for instance in patients with typical or atypical symptoms of gastroesophageal reflux disease and in NSAID or aspirin users at risk of gastrotoxicity and related complications including hemorrhage, perforation and gastric outlet obstruction. Long-term use of PPIs may lead to potential adverse effects, such as osteoporotic fracture, renal damage, infection (pneumonia and clostridium difficile infection), rhabdomyolysis, nutritional deficiencies (vitamin B12, magnesium and iron), anemia and thrombocytopenia. In this article, we will review some novel uses of PPIs in other fields and summarize the underlying adverse reactions.