Processing of facial expressions and their significance for the observer in subregions of the human amygda
Processing of facial expressions and their significance for the observer in subregions of the human amygda
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DOI：
10.1016/j.neuroimage.2011.02.021
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发表时间：
2011-05-01
期刊：
影响因子：
5.7
通讯作者：
Buechel, Christian
中科院分区：
文献类型：
--
作者：
Boll, Sabrina;Gamer, Matthias;Buechel, Christian
杏仁核对情绪化面孔的反应会受到伴随注视方向的影响。作为一种解释，有人提出，观察者使用眼睛凝视作为一种线索来破译潜在威胁的来源，以评估情况的重要性。为了验证这一假设，我们保持视线方向模糊，并替换可能由视线方向提供的信息与h明确的，上下文信息的意图愤怒和恐惧的面孔。使用功能磁共振成像，我们表明，这种操纵唤起了类似的模式，杏仁核激活先前的凝视相关的帐户：愤怒的面孔针对观察者引起更强的杏仁核反应比愤怒的面孔针对另一个人，而相反的模式，观察到恐惧的面孔。我们进一步结合我们的范例与高分辨率的功能磁共振成像，使我们能够本地化集群的激活杏仁核亚区：纯粹的面部表情诱发信号的变化，观察在副基底核，而我们的数据表明皮质杏仁核的关键作用，在连接上下文信息的情绪面孔，并在破译的意义，面孔的观察者。(C)2011 Elsevier Inc. All rights reserved.
Amygdala responses to emotional faces can be influenced by concomitant gaze direction. As an explanation it has been suggested that the observer uses eye gaze as a cue to decipher the source of a potential threat in order to evaluate the significance of the situation. To test this assumption, we kept gaze direction ambiguous and replaced the information possibly provided by gaze direction with h explicit, contextual information about intentions of angry and fearful faces. Using fMRI we show that this manipulation evokes a similar pattern of amygdala activation as prior gaze-related accounts: angry faces targeting at the observer elicited stronger amygdala responses than angry faces targeting at another person, whereas the opposite pattern was observed for fearful faces. We further combined our paradigm with high-resolution fMRI which enabled us to localize clusters of activation in amygdala subregions: purely facial-expression evoked signal changes were observed in the accessory basal nucleus, whereas our data suggest a critical role of the corticomedial amygdala in linking contextual information to emotional faces and in deciphering the significance of the faces for the observer. (C) 2011 Elsevier Inc. All rights reserved.