Highly diastereo- and enantioselective Mannich reaction of lactones with N-Boc-aldimines catalyzed by bifunctional rosin-derived amine thiourea catalysts
Highly diastereo- and enantioselective Mannich reaction of lactones with N-Boc-aldimines catalyzed by bifunctional rosin-derived amine thiourea catalysts
复制标题
双功能松香衍生胺硫脲催化剂催化内酯与 N-Boc-醛亚胺的高度非对映和对映选择性曼尼希反应
DOI：
10.1039/c000621a
复制
发表时间：
2010-01-01
影响因子：
4.9
通讯作者：
Wang, Rui
中科院分区：
文献类型：
--
作者：
Jiang, Xianxing;Fu, Dan;Wang, Rui
首次研究了双功能松香胺硫脲催化下内酯与N-叔丁氧羰基醛亚胺的Mannich反应，得到了具有高对映体和非对映体选择性的四元立体中心加合物（ee值高达99%，dr> 20：1）.
A highly efficient diastereo- and enantioselective Mannich reaction of lactones with a variety of N-Boc-aldimines by using bifunctional rosin-derived amine thiourea catalysts was investigated for the first time, in general, affording the adducts bearing quaternary stereogenic centers with high levels of enantio-and diastereoselectivity (up to 99% ee, and > 20 : 1 dr).