Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results
Sensorimotor gating in boys with Tourette's syndrome and ADHD: Preliminary results
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DOI：
10.1016/0006-3223(95)00101-8
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发表时间：
1996-01-01
影响因子：
10.6
通讯作者：
Hallett, M
中科院分区：
文献类型：
--
作者：
Castellanos, FX;Fine, EJ;Hallett, M
在动物和临床研究中，由前脉冲抑制（PPI）定义的感觉运动门控缺陷与皮层下多巴胺能过度活动有关。利用眶上神经电刺激，我们产生了足够的眨眼反应，并测量了略高于感觉阈值的电前刺激导致的振幅下降。与 14 名筛查对照组和 7 名仅患有 ADHD 的男孩相比，7 名同时患有注意力缺陷多动障碍 (ADHD) 和抽动障碍的男孩的 PPI 显着降低。如果独立重复，这些结果可能反映出这些共病受试者的神经系统更加不成熟。或者，这些发现与其他汇聚的证据一起表明，苍白球抑制缺陷可能与病因学相关的抽动和运动障碍有关。
Deficits in sensorimotor gating, defined by prepulse inhibition (PPI), have been associated with subcortical dopaminergic overactivity in animal and clinical studies, Utilizing supraorbital nerve electrical stimulation, we produced adequate blink responses and measured decreases in amplitude resulting from electric prestimuli just above sensory threshold. Seven boys comorbid for attention-deficit hyperactivity disorder (ADHD) and a tic disorder had significantly reduced PPI, compared to 14 screened controls and seven boys with ADHD alone. If independently replicated, these results may reflect greater neurologic immaturity in these comorbid subjects. Alternatively, these findings, together with other converging lines of evidence, suggest that deficient pallidal inhibition may be etiologically related so tic and movement disorders.