Tissue engineering: The challenges ahead
Tissue engineering: The challenges ahead
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DOI：
10.1038/scientificamerican0499-86
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发表时间：
1999-04-01
影响因子：
3
通讯作者：
Vacanti, JP
中科院分区：
文献类型：
--
作者：
Langer, RS;Vacanti, JP
版权所有1999 Scientific American，Inc.在生物反应器中搅拌的胶原蛋白珠的基础上培养的细胞比在平的固定培养皿中培养的细胞产生更多的骨矿物质。劳拉·E.现在就职于杜克大学的Niklason已经证明，由内皮细胞（血管衬里）和平滑肌细胞制成的组织工程小动脉，如果有生长培养基通过它们来模拟跳动的心脏产生的血压，就会产生更类似于天然血管的机械特性。包括我们在内的其他几个研究小组正在研究生长骨骼肌和心肌的方法，这些组织在对身体压力做出反应时会变得更强壮。
Copyright 1999 Scientific American, Inc. cultured on a base of collagen beads being stirred in a bioreactor make more bone minerals than they do when they are grown in a flat, stationary dish. And Laura E. Niklason, who is now at Duke University, has demonstrated that tissue-engineered small arteries made of endothelial cells (blood vessel lining) and smooth muscle cells shaped into tubes develop mechanical properties more akin to natural blood vessels if they have growth medium pulsed through them to imitate the blood pressure generated by a beating heart. Several other teams—including ours—are developing ways to grow skeletal and cardiac muscle, tissues that become stronger as they respond to physical stress.