Growth Trajectories, Breast Size, and Breast-Tissue Composition in a British Prebirth Cohort of Young Women.
Growth Trajectories, Breast Size, and Breast-Tissue Composition in a British Prebirth Cohort of Young Women.
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英国产前年轻女性队列的生长轨迹、乳房大小和乳房组织组成。
DOI：
10.1093/aje/kwx358
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发表时间：
2018
影响因子：
5
通讯作者：
Denholm R
中科院分区：
文献类型：
--
作者：
Denholm R
乳房X光摄影百分比密度，即乳房中纤维腺组织的比例，是乳腺癌的强烈风险因素，但其在年轻女性中的决定因素尚不清楚。我们研究了21岁时磁共振成像(MRI)与前瞻性收集的从出生到成年早期的身体大小和组成以及青春期标志(都是标准化的)之间的关系，从1991年到1992年出生在英国雅芳的出生前队列中的500名未分娩妇女，并对其进行了跟踪调查，直到2011-2014年。线性模型被用来估计MRI百分比水分的相对变化，这相当于乳房X光摄影百分比密度，与感兴趣的暴露增加1个标准差有关。在相互调整的分析中，MRI百分比水分与出生体重(相对变化(RC)=1.03，95%可信区间(CI)：1.00，1.06)和青春期身高增长(RC=1.07，95%CI：1.02，1.13)呈正相关，而与青春期体重增长(RC=0.86，95%CI：0.84，0.89)和双能X线吸收法百分比体脂质量的变化(例如，11岁至13.5岁之间的变化，RC=0.96，95%可信区间：0.93，0.99)。初潮年龄和月经初潮年龄与MRI百分比水分呈正相关，但在对身高和体重增长进行调整后，这些关联并不持续。这些发现支持这样一种假设，即生长轨迹影响年轻女性的乳房组织组成，而青春期不起独立作用。
Mammographic percent density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations of magnetic resonance imaging (MRI) breast-tissue composition at age 21 years with prospectively collected measurements of body size and composition from birth to early adulthood and markers of puberty (all standardized) in a sample of 500 nulliparous women from a prebirth cohort of children born in Avon, United Kingdom, in 1991–1992 and followed up to 2011–2014. Linear models were fitted to estimate relative change in MRI percent water, which is equivalent to mammographic percent density, associated with a 1–standard-deviation increase in the exposure of interest. In mutually adjusted analyses, MRI percent water was positively associated with birth weight (relative change (RC) = 1.03, 95% confidence interval (CI): 1.00, 1.06) and pubertal height growth (RC = 1.07, 95% CI: 1.02, 1.13) but inversely associated with pubertal weight growth (RC = 0.86, 95% CI: 0.84, 0.89) and changes in dual-energy x-ray absorptiometry percent body fat mass (e.g., for change between ages 11 years and 13.5 years, RC = 0.96, 95% CI: 0.93, 0.99). Ages at thelarche and menarche were positively associated with MRI percent water, but these associations did not persist upon adjustment for height and weight growth. These findings support the hypothesis that growth trajectories influence breast-tissue composition in young women, whereas puberty plays no independent role.