Ultrasmall Superparamagnetic Particles of Iron Oxide in Patients With Acute Myocardial Infarction Early Clinical Experience
Ultrasmall Superparamagnetic Particles of Iron Oxide in Patients With Acute Myocardial Infarction Early Clinical Experience
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DOI：
10.1161/circimaging.112.974907
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发表时间：
2012-09-01
影响因子：
7.5
通讯作者：
Semple, Scott I. K.
中科院分区：
文献类型：
--
作者：
Alam, Shirjel R.;Shah, Anoop S. V.;Semple, Scott I. K.
背景--急性心肌梗死(MI)后的炎症对再灌注、心肌重构和心功能有不利影响。使用超小超顺磁性氧化铁颗粒的磁共振成像可以检测组织中的细胞炎症，因此我们探讨了它们在人类急性心肌梗死中的作用。方法和结果-16例急性ST段抬高心肌梗死患者在基线入院5天内、不输注(对照组)24小时和48小时后(n=6)或静脉输注超小超顺磁性氧化铁颗粒(n=10；4 mg/kg)进行了3次连续磁共振扫描。采集T2*加权多梯度回波序列，并计算特定感兴趣区域的R2*值。在对照组中，所有组织的R2*值在所有扫描中保持不变，具有良好的重复性(偏差为-0.208 S(-1)，重复性系数为26.96 S(-1)；组内系数为0.989)。与网状内皮系统摄取一致，注射超小超顺磁性氧化铁24小时后，肝脏R2*值增加(84+/-49.5to319+/-70.0 S(-1)；P005)。在心肌梗塞中，R2*值从41.0+/-12.0 S(-1)上升到155+/-45.0 S(-1)(P
Background-Inflammation following acute myocardial infarction (MI) has detrimental effects on reperfusion, myocardial remodelling, and ventricular function. Magnetic resonance imaging using ultrasmall superparamagnetic particles of iron oxide can detect cellular inflammation in tissues, and we therefore explored their role in acute MI in humans.Methods and Results-Sixteen patients with acute ST-segment elevation MI were recruited to undergo 3 sequential magnetic resonance scans within 5 days of admission at baseline, 24 and 48 hours following no infusion (controls; n=6) or intravenous infusion of ultrasmall superparamagnetic particles of iron oxide (n=10; 4 mg/kg). T2*-weighted multigradient-echo sequences were acquired and R2* values were calculated for specific regions of interest. In the control group, R2* values remained constant in all tissues across all scans with excellent repeatability (bias of -0.208 s(-1), coefficient of repeatability of 26.96 s(-1); intraclass coefficient 0.989). Consistent with uptake by the reticuloendothelial system, R2* value increased in the liver (84 +/- 49.5 to 319 +/- 70.0 s(-1); P0.05) 24 hours after administration of ultrasmall superparamagnetic particles of iron oxide. In the myocardial infarct, R2* value increased from 41.0 +/- 12.0 s(-1) (baseline) to 155 +/- 45.0 s(-1) (P