γ oscillations in schizophrenia: mechanisms and clinical significance.
γ oscillations in schizophrenia: mechanisms and clinical significance.
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精神分裂症中的γ振荡：机制和临床意义。
DOI：
10.1016/j.brainres.2011.06.065
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发表时间：
2011
期刊：
影响因子：
2.9
通讯作者：
Daskalakis,ZafirisJ
中科院分区：
文献类型：
--
作者：
Sun,Yinming;Farzan,Faranak;Barr,MeraS;Kirihara,Kenji;Fitzgerald,PaulB;Light,GregoryA;Daskalakis,ZafirisJ
脑震荡越来越多地用于理解复杂的精神疾病。伽马（30- 50 Hz）振荡由于其在认知任务中的无处不在而值得特别关注。对于精神分裂症（SCZ）患者，一种与认知不良相关的疾病，在许多实验范例中已经报道了异常伽马振荡。本文的目的是回顾文献中SCZ的伽玛振荡。审查分为四个部分。首先，功能的作用，神经生物学和脑振荡，特别是伽马振荡的分析将概述。第二，神经生物学异常SCZ有关的伽玛振荡将进行审查。第三，选定的范例调查不规则的伽玛振荡SCZ将详细讨论。最后，讨论了目前研究结果的局限性和未来的研究方向。回顾的证据表明，伽马振荡在SCZ中被破坏，并且可以解释这种疾病中的认知障碍。通过额外的分析和实验，这些指标最终可能作为内表型，促进基于病因的诊断方法的发展，促进早期识别和治疗，并促进我们对这种疾病所涉及的复杂遗传机制的理解。
Brain oscillations are increasingly used for understanding complex psychiatric disorders. Gamma (30–50Hz) oscillations have warranted special attention due to their omnipresence in cognitive tasks. For patients with schizophrenia (SCZ), a disease associated with poor cognition, abnormal gamma oscillations have been reported in many experimental paradigms. The goal of this paper is to review the literature on gamma oscillations in SCZ. The review is structured into four sections. First, the functional role, neurobiology, and analysis of brain oscillations, especially gamma oscillations will be outlined. Second, the neurobiological abnormalities of SCZ in relation to gamma oscillations will be reviewed. Third, selected paradigms for investigating irregular gamma oscillations in SCZ will be discussed in detail. Finally, a discussion on the limitations of current findings and potential future research directions will be provided. The reviewed evidence suggests that gamma oscillations are disrupted in SCZ and could account for cognitive disturbances in this disorder. With additional analysis and experimentation, these indices may ultimately serve as endophenotypes that facilitate the development of etiologically based diagnostic methods, foster early identification and treatment, and advance our understanding of the complex genetic mechanisms involved in this disorder.