Genetic and psychosocial factors in schizophrenia: the Finnish Adoptive Family Study.
Genetic and psychosocial factors in schizophrenia: the Finnish Adoptive Family Study.
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精神分裂症的遗传和心理社会因素：芬兰收养家庭研究。
DOI：
10.1093/schbul/13.3.477
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发表时间：
1987
影响因子：
6.6
通讯作者：
Wynne,LC
中科院分区：
文献类型：
--
作者：
Tienari,P;Sorri,A;Lahti,I;Naarala,M;Wahlberg,KE;Moring,J;Pohjola,J;Wynne,LC
芬兰全国范围内的精神分裂症母亲的后代被放弃收养的样本与数学控制（即，非精神分裂症亲生父母被收养的后代）进行了盲目比较。后代出生在1927年至1979年。迄今为止，共对247个收养家庭（112个指数家庭和135个对照家庭）进行了调查和评级。在10例精神病患者中，8例是精神分裂症患者的后代，2例是对照后代。然而，在健康或轻度紊乱的收养家庭中没有发现严重紊乱的后代，而在那些患有精神病或严重紊乱的后代中，几乎所有的后代都是在紊乱的收养家庭中长大的。这支持了一种可能的遗传脆弱性与收养抚养环境相互作用的假设。
A nationwide Finnish sample of schizophrenic mothers' offspring given up for adoption was compared blindly with matthed controls (i.e., adopted-away offspring of nonschizophrenic biological parents). The offspring were born 1927–79. To date, a total of 247 adoptive families (112 index and 135 controls) have been investigated and rated. Of the 10 psychotic cases, 8 are offspring of schizophrenics and 2 are control offspring. However, no seriously disturbed offspring is found in a healthy or mildly disturbed adoptive family, and of those offspring who were psychotic or seriously disturbed, nearly all were reared in disturbed adoptive families. This supports the hypothesis that a possible genetic vulnerability has interacted with the adoptive rearing environment.