Sperm maturation in the epididymis: a new look at an old problem
Sperm maturation in the epididymis: a new look at an old problem
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DOI：
10.1111/j.1745-7262.2007.00285.x
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发表时间：
2007-07-01
影响因子：
2.9
通讯作者：
Cooper, Trevor G.
中科院分区：
文献类型：
--
作者：
Cooper, Trevor G.
成熟精子所面临的渗透挑战及其对这些挑战的反应与精子成熟的概念有关，精子成熟的定义是当精子进入雌性生殖道时，远端恢复的附睾精子使卵子受精的能力增加。一种解释可能是，越远的细胞能够更好地调节它们的体积，并到达输卵管，作为附睾渗透液摄取的结果。附睾内也获得了增强的运动性、带结合和胚膜融合能力，这对最终到达受精地点的细胞是必要的。
The osmotic challenges facing maturing spermatozoa and their responses to them are discussed in relation to the concept of sperm maturation, defined as the increased ability of more distally recovered epididymal spermatozoa to fertilize eggs when inseminated into the female tract. One explanation could be that the more distal cells are better able to regulate their volume, and reach the oviducts, as a consequence of uptake of epididymal osmolytes. Increased motility, zona binding and oolemma fusion capacities are also acquired within the epididymis and are necessary for those cells that finally arrive at the site of fertilization.