Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity.
Nonapoptotic caspases in neural development and in anesthesia-induced neurotoxicity.
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DOI：
10.1016/j.tins.2022.03.007
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发表时间：
2022-06
影响因子：
15.9
通讯作者：
Ishibashi, Nobuyuki
中科院分区：
文献类型：
--
作者：
Sari, Nemanja;Hashimoto-Torii, Kazue;Jevtovic-Todorovic, Vesna;Ishibashi, Nobuyuki
关键词：
细胞凋亡，经典地由半胱天冬酶途径激活启动，在正常脑发育以及神经退行性变中起着突出的作用。半胱天冬酶途径的非经典、非致死性臂在进化上是保守的，并且也与这两个过程有关，但相对而言研究不足。在神经发育的关键时期，由于环境神经毒素或暴露于麻醉剂等化合物而导致的通路激活失调可能对大脑成熟和行为产生长期影响。在这篇综述中，我们讨论了关键的分子特征和作用的非经典的caspase途径，以及如何其失调可能会对大脑发育产生不利影响。我们强调了调节凋亡和亚致死性caspase反应的遗传和环境因素，并讨论了针对发育性脑损伤的非经典caspase途径的潜在干预措施。
Apoptosis, classically initiated by caspase pathway activation, plays a prominent role during normal brain development as well as in neurodegeneration. The non-canonical, non-lethal arm of the caspase pathway is evolutionarily conserved and has also been implicated in both processes, yet is relatively understudied. Dysregulated pathway activation during critical periods of neurodevelopment due to environmental neurotoxins or exposure to compounds such as anesthetics can have detrimental consequences for brain maturation and long-term effects on behavior. In this review, we discuss key molecular characteristics and roles of the non-canonical caspase pathway and how its dysregulation may adversely affect brain development. We highlight both genetic and environmental factors that regulate apoptotic and sub-lethal caspase responses, and discuss potential interventions that target the non-canonical caspase pathway for developmental brain injuries.
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影响因子：
4
作者：
Del Rio R;Quintanilla RA;Orellana JA;Retamal MA
通讯作者：
Retamal MA
DOI：
10.1016/s0140-6736(15)00608-x
发表时间：
2016-01-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Davidson AJ;Disma N;de Graaff JC;Withington DE;Dorris L;Bell G;Stargatt R;Bellinger DC;Schuster T;Arnup SJ;Hardy P;Hunt RW;Takagi MJ;Giribaldi G;Hartmann PL;Salvo I;Morton NS;von Ungern Sternberg BS;Locatelli BG;Wilton N;Lynn A;Thomas JJ;Polaner D;Bagshaw O;Szmuk P;Absalom AR;Frawley G;Berde C;Ormond GD;Marmor J;McCann ME;GAS consortium
通讯作者：
GAS consortium
DOI：
10.1016/j.jtcvs.2016.03.095
发表时间：
2016-08
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Diaz LK;Gaynor JW;Koh SJ;Ittenbach RF;Gerdes M;Bernbaum JC;Zackai EH;Clancy RR;Rehman MA;Pennington JW;Burnham N;Spray TL;Nicolson SC
通讯作者：
Nicolson SC
影响因子：
4.8
作者：
Fernando, P;Brunette, S;Megeney, LA
通讯作者：
Megeney, LA
影响因子：
8.8
作者：
Dong C;Rovnaghi CR;Anand KJ
通讯作者：
Anand KJ