Expression of neural BC1 RNA: Induction in murine tumours
Expression of neural BC1 RNA: Induction in murine tumours
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DOI：
10.1016/s0959-8049(96)00453-4
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发表时间：
1997-02-01
影响因子：
8.4
通讯作者：
Tiedge, H
中科院分区：
文献类型：
--
作者：
Chen, W;Heierhorst, J;Tiedge, H
BC 1 RNA是在啮齿动物神经系统中表达的小细胞质RNA聚合酶III转录物。RNA选择性地在神经元中表达，其位于体树突结构域中。BC 1 RNA通常在非神经元体细胞中不可检测;然而，它在生殖细胞和各种非神经来源的培养的永生细胞系中表达。因此，我们试图建立是否BC 1表达的神经元特异性调节在非神经肿瘤细胞中改变。使用北方转移和原位杂交分析致癌物和化学致癌物诱导的小鼠肿瘤中BC 1 RNA的存在。在这里，我们报告BC 1 RNA选择性地在肿瘤细胞中表达，但在相应的正常组织中不表达。这些结果表明，BC 1表达的神经特异性调节在非神经来源的鼠肿瘤细胞中缺乏。(C)1997 Elsevier Science Ltd.
BC1 RNA is a small cytoplasmic RNA polymerase III transcript that is expressed in the rodent nervous system. The RNA is selectively expressed in neurons where it is located in somatodendritic domains. BC1 RNA is not normally detectable in non-neuronal somatic cells; it is however expressed in germ cells and in cultured immortal cell lines of various non-neural origins. We therefore sought to establish whether the neuron-specific regulation of BC1 expression is altered in nonneural tumour cells. Oncogen and chemical carcinogen induced mouse tumours were analysed for the presence of BC1 RNA, using Northern transfer and in situ hybridisation. Here we report that BC1 RNA is selectively expressed in tumour cells, but not in corresponding normal tissues. These results indicate that neural-specific regulation of BC1 expression is lacking in murine tumour cells of non-neural origin. (C) 1997 Elsevier Science Ltd.