Molecular neurodevelopment: an in vivo 31P-1H MRSI study.
Molecular neurodevelopment: an in vivo 31P-1H MRSI study.
复制标题
DOI：
10.1017/s1355617709990233
复制
发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Pettegrew JW
中科院分区：
文献类型：
--
作者：
Goldstein G;Panchalingam K;McClure RJ;Stanley JA;Calhoun VD;Pearlson GD;Pettegrew JW
突触的发育和消除是正常的神经发育过程，如果改变可能导致各种神经精神疾病。对106例6 ~ 18岁健康儿童进行31P-1H磁共振波谱成像和结构MRI检查，以确定突触发育和消除的神经分子指标。在研究的年龄范围内，发现高能磷酸盐（磷酸肌酸）、膜磷脂代谢（前体和分解产物）和灰质的年龄相关变化。这些突触发育和消除的神经分子和结构指标与几个认知领域的发展和灰质体积的变化有关。监测这些分子标记对于制定神经发育障碍的治疗策略至关重要。
Synaptic development and elimination are normal neurodevelopmental processes which if altered could contribute to various neuropsychiatric disorders. 31P-1H magnetic resonance spectroscopic imaging and structural MRI exams were conducted on 106 healthy children ages 6–18 years in order to identify neuromolecular indices of synaptic development and elimination. Over the age range studied, age-related changes in high-energy phosphate (phosphocreatine), membrane phospholipid metabolism (precursors and breakdown products), and gray matter were found. These neuromolecular and structural indices of synaptic development and elimination are associated with development of several cognitive domains and changes in gray matter volume. Monitoring of these molecular markers is essential for devising treatment strategies for neurodevelopmental disorders.