Relative biological effectiveness of ionizing radiations determined in tissue (RBE) fails in assessing comparative relative effectiveness in the tissue cells
Relative biological effectiveness of ionizing radiations determined in tissue (RBE) fails in assessing comparative relative effectiveness in the tissue cells
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DOI：
10.1097/00004032-199606000-00011
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发表时间：
1996-06-01
期刊：
影响因子：
2.2
通讯作者：
Sondhaus, CA
中科院分区：
文献类型：
--
作者：
Feinendegen, LE;Bond, VP;Sondhaus, CA
测试辐射的RBE值是传统决定与一个已知的标准辐射的选择反应选择的生物组织和表示为组织吸收剂量的比例相等的效果,或者是比效应的大小等于吸收剂量,如果这样的效果是可观测的结果的反应各个元素的组织,即细胞,如感应来自单个细胞的癌症,相对生物有效性应表示为在等平均吸收剂量下效应对细胞的发生率之比，而不是在等吸收剂量下对组织的发生率之比。这种基于细胞的相对生物有效性在这里称为相对局部效率，因为组织吸收剂量是该组织细胞中能量沉积事件的数量（N-H）与暴露组织中这些细胞的平均吸收剂量（）的乘积。每组织质量相同的不同辐射质量的组织吸收剂量具有不同的N-H值，因此，对于Tradescantia细胞中的粉红色突变，0.43 MeV中子的相对生物有效性为48，但实际上相对局部效率为2.8。
The value of the RBE of a test radiation is conventionally determined against a known standard radiation for a chosen response of a selected biological tissue and is expressed as the ratio of tissue absorbed doses at equal effect, or as ratio of magnitudes of the effect at equal absorbed dose, If such an effect is observable as a consequence of responses of individual elements of this tissue, namely the cells, such as induction of cancer that arises from a single cell, the relative biological effectiveness should be expressed as the ratio of the incidences of the effects at equal mean absorbed dose to the cells rather than at equal absorbed dose to tissue, This cell based relative biological effectiveness is here termed the relative local efficiency, Since tissue absorbed dose is a product of the number of energy deposition events in cells of that tissue (N-H) and the mean absorbed dose to these cells in the exposed tissue (), per tissue mass equal tissue absorbed doses from different radiation qualities have different values of N-H and , As a result, for pink mutations in Tradescantia cells, the relative biological effectiveness of 0.43 MeV neutrons is 48 but the relative local efficiency in fact is 2.8.