A Low-Loss Cascade Impactor with Stage Collection Cups: Calibration and Pharmaceutical Inhaler Applications
A Low-Loss Cascade Impactor with Stage Collection Cups: Calibration and Pharmaceutical Inhaler Applications
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带有阶段收集杯的低损耗级联冲击器：校准和药物吸入器应用
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
N. C. Miller
中科院分区：
文献类型：
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作者：
V. Marple;B. Olson;N. C. Miller
描述了一种具有低级间损失的新型级联冲击器设计。一个新颖的特点是使用外部阶段收集杯，以简化需要对每个阶段收集的质量进行化学测定的应用。该设计已在两种流量下运行：30 升/分钟和 60 升/分钟。提供了这些流速的校准数据，此外还提供了后一个版本 90 L/min 的校准数据。使用新型冲击器对典型药物吸入产品的尺寸结果与使用当前级联冲击器获得的尺寸结果相同。提供了一个示例来说明在多个流速下收集尺寸数据的效用。
A new cascade impactor design having low interstage losses is described. A novel feature is the use of external stage collection cups, to simplify applications requiring chemical determination of the mass collected on each stage. The design has been executed in versions to operate at two flow rates: 30 and 60 L/min. Calibration data are presented for these flow rates, and, in addition, for the latter version at 90 L/min. Size results using the new impactor on a typical pharmaceutical inhalation product are shown to be equivalent to those obtained using a current cascade impactor. An example is presented to indicate the utility of gathering size data at more than one flow rate.