Effect of exercise therapy combined with branched-chain amino acid supplementation on muscle strength in elderly women after total hip arthroplasty: a randomized controlled trial
Effect of exercise therapy combined with branched-chain amino acid supplementation on muscle strength in elderly women after total hip arthroplasty: a randomized controlled trial
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DOI：
10.6133/apjcn.201912_28(4).0007
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发表时间：
2019-12-01
影响因子：
1.3
通讯作者：
Jinno, Tetsuya
中科院分区：
文献类型：
--
作者：
Ikeda, Takashi;Matsunaga, Yuki;Jinno, Tetsuya
背景与目的：许多患者在全髋关节置换术（THA）后尽管重建了髋关节，但仍会出现长期的肌力下降。据报道，体育锻炼结合支链氨基酸（BCAA）补充剂可改善患有肌肉减少症的老年人的肌肉力量。然而，全髋关节置换术后补充支链氨基酸的效果尚不清楚。本研究探讨了补充支链氨基酸结合运动疗法对老年患者全髋关节置换术后身体功能改善的影响。方法和研究设计：受试者为31名接受THA的老年女性。参与者被随机分配到两组：BCAA（n=18）和对照组（n=13）。术后1个月进行综合治疗。对于运动干预，进行了3组体育锻炼计划。对于营养干预，参与者在运动干预后立即摄入3.4 g BCAA补充剂或1.2 g淀粉。结果如下：补充支链氨基酸结合肌肉强化练习对对侧膝关节伸展力量和上臂横截面积有显着影响。BCAA组手术侧干预前后伸膝力量改善率也明显高于对照组。结论：补充支链氨基酸与体育锻炼相结合可有效提高患者部分肌肉的力量，但对手术侧髋外展肌的力量无明显改善。未来的研究需要确定这种联合治疗对髋外展肌肌力的疗效。
Background and Objectives: Many patients develop a prolonged decrease of muscle strength after total hip arthroplasty (THA) despite their reconstructed hip joint. Physical exercise combined with branched-chain amino acid (BCAA) supplementation has been reported to improve muscle strength in elderly persons with sarcopenia. However, the effect of BCAA supplementation in patients after THA is unknown. This study examined the effects of BCAA supplementation combined with exercise therapy on the improvement of physical function in elderly patients after THA. Methods and Study Design: The subjects were 31 elderly women who underwent THA. The participants were randomly assigned to two groups: BCAA (n=18) and control (n=13). The combined therapy was carried out for one month after THA. For the exercise intervention, a 3-set physical exercise program was conducted. For the nutritional intervention, the participants consumed 3.4 g of BCAA supplement or 1.2 g of starch immediately after the exercise intervention. Results: BCAA supplementation combined with muscle strengthening exercises had a significant effect on knee extension strength of the contralateral side and on upper arm cross-sectional area. The improvement ratio of knee extension strength before and after intervention on the operated side was also significantly higher in the BCAA group. Conclusions: BCAA supplementation is effective for patients to improve the strength of some muscles when combined with physical exercises, but hip abductor muscle strength of the operated leg did not improve. A future study is needed to determine the efficacy of this combined therapy for hip abductor muscle strength.