Control of growth and normal differentiation in leukemic cells: Regulation of the developmental program and restoration of the normal phenotype in myeloid leukemia
Control of growth and normal differentiation in leukemic cells: Regulation of the developmental program and restoration of the normal phenotype in myeloid leukemia
复制标题
控制白血病细胞的生长和正常分化：调节髓系白血病的发育程序和恢复正常表型
DOI：
10.1002/jcp.1041130423
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发表时间：
1982
影响因子：
5.6
通讯作者：
L. Sachs
中科院分区：
文献类型：
--
作者：
L. Sachs
恶性肿瘤的起源和演变涉及一系列遗传变化。然而，已经从各种类型的肿瘤中获得了证据，表明恶性细胞并没有失去控制正常生长和分化的基因。体外克隆和细胞培养系统已被开发，以确定和解剖控制，调节正常骨髓细胞的生长，分化和恶性，并提出了一种新的方法来治疗骨髓性白血病的基础上诱导恶性细胞的正常分化。通过分化的生理诱导剂、巨噬细胞和粒细胞诱导蛋白MGI的适当分子形式诱导正常细胞分化和恢复髓性白血病的正常表型的实验也被用于制定调控发育程序和恶性肿瘤起源和演变的一般模型。
The origin and evolution of malignancy involves a sequence of genetic changes. Evidence has, however, been obtained with various types of tumors that malignant cells have not lost the genes that control normal growth and differentiation. An in vitro cloning and cell culture system has been developed to determine and dissect the controls that regulate normal myeloid cell growth, differentiation, and malignancy and to suggest a new approach to the therapy of myeloid leukemia based on the induction of normal differentiation in malignant cells. Experiments on induction of normal cell differentiation and restoration of the normal phenotype in myeloid leukemia by the physiological inducer of differentiation, the appropriate molecular form of the macrophage and granulocyte‐inducing protein MGI, have also been used to formulate a general model for regulation of developmental programs and the origin and evolution of the malignancy.