MAGUKs are essential, but redundant, in long-term potentiation
MAGUKs are essential, but redundant, in long-term potentiation
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DOI：
10.1073/pnas.2107585118
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发表时间：
2021-07-13
影响因子：
11.1
通讯作者：
Nicoll, Roger A.
中科院分区：
文献类型：
--
作者：
Chen, Xiumin;Fukata, Yuko;Nicoll, Roger A.
这项研究提供的证据表明，Maguk家族的突触支架蛋白在长时程增强(LTP)中发挥着必要的但多余的作用。PSD-95的作用，而不是SAP102的作用，需要与跨突触黏附蛋白ADAM22结合，这是纳米柱稳定所必需的。基于这些和以前的结果，我们提出了一个在LTP期间招募AMPAR的两步过程。首先，AMPAR通过防水油布与PSD中暴露的PSD-95绑定。单靠这一点还不足以增强突触传递。其次，AMPAR/TARP/PSD-95复合体通过与ADAM22结合而稳定在纳米柱中。对于SAP102，提出了第二个ADAM22非依赖的途径。
This study presents evidence that the MAGUK family of synaptic scaffolding proteins plays an essential, but redundant, role in longterm potentiation (LTP). The action of PSD-95, but not that of SAP102, requires the binding to the transsynaptic adhesion protein ADAM22, which is required for nanocolumn stabilization. Based on these and previous results, we propose a two-step process in the recruitment of AMPARs during LTP. First, AMPARs, via TARPs, bind to exposed PSD-95 in the PSD. This alone is not adequate to enhance synaptic transmission. Second, the AMPAR/ TARP/PSD-95 complex is stabilized in the nanocolumn by binding to ADAM22. A second, ADAM22-independent pathway is proposed for SAP102.