ANDROGENIC CONTROL OF FOOD-INTAKE AND BODY-WEIGHT IN MALE RATS
ANDROGENIC CONTROL OF FOOD-INTAKE AND BODY-WEIGHT IN MALE RATS
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DOI：
10.1037/h0077264
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发表时间：
1976-01-01
期刊：
影响因子：
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通讯作者：
WADE, GN
中科院分区：
文献类型：
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作者：
GENTRY, RT;WADE, GN
用118只成年Sprague-Dawley大鼠进行了2项实验，以比较雄激素与雌激素的作用，并检查靶组织代谢在睾酮对体重作用中的作用。成年雄性动物的去势产生了延迟（1个月）、永久性食欲减退和体重增加减少。这与女性卵巢切除术引起的快速、短暂的食欲过盛和体重增加形成对比。注射丙酸睾酮（TP）刺激去势雄性动物的摄食量和体重增加。无论是5 α-还原，也不芳构化的睾酮分子发挥了重要作用，在刺激这些措施的TP。TP的5 α还原代谢物5 α-丙酸二氢睾酮（DHTP）在增加进食和体重增加方面不如TP有效。非常高剂量的TP实际上减少了体重增加，延长治疗（2-6周）。这表明，这种减少的体重增加是由于芳构化的TP的雌激素。非芳香化雄激素，DHTP，即使在非常高的剂量下也没有减少体重增加，同时注射孕酮逆转了高剂量TP的减肥作用。(38参考）（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Conducted 2 experiments with 118 adult Sprague-Dawley rats to compare the effects of androgens with those of estrogens and examine the role of target-tissue metabolism in actions of testosterone on body weight. Castration of adult males produced a delayed (by 1 mo), permanent hypophagia and reduction in weight gain. This contrasted with the rapid, transient hyperphagia and increased weight gain caused by ovariectomy in females. Injections of testosterone propionate (TP) stimulated food intake and weight gain in castrated males. Neither 5alpha-reduction nor aromatization of the testosterone molecule played an important role in the stimulation of these measures by TP. The 5alpha-reduced metabolite of TP, 5alpha-dihydrotestosterone propionate (DHTP), was less effective in increasing eating and weight gain than was TP. Very high doses of TP actually reduced weight gain with prolonged treatment (2-6 wks). It is suggested that this reduced weight gain was due to aromatization of TP to an estrogen. The nonaromatizable androgen, DHTP, did not reduce weight gain even in very high doses, and concurrent progesterone injections reversed the weight-reducing actions of high TP doses.(38 ref)(PsycINFO Database Record (c) 2016 APA, all rights reserved)