MicroRNA in Human Glioma.
MicroRNA in Human Glioma.
复制标题
人类神经胶质瘤中的 MicroRNA。
DOI：
10.3390/cancers5041306
复制
发表时间：
2013-10-23
期刊：
影响因子：
5.2
通讯作者：
Yuan J
中科院分区：
文献类型：
--
作者：
Li M;Li J;Liu L;Li W;Yang Y;Yuan J
神经胶质瘤是一个全球性的严重健康问题。尽管在手术、放疗、化疗和靶向治疗方面取得了进展，但该疾病仍然是人类最致命的恶性肿瘤之一，迫切需要新的方法来提高抗胶质瘤治疗的疗效。因此，新的治疗靶点和工具应该基于对胶质瘤分子发病机制的更好理解而开发。在这种情况下，microRNAs (miRNAs)，一类小的非编码rna，在胶质瘤细胞恶性表型的发展中起着关键作用，包括细胞存活、增殖、分化、肿瘤血管生成和干细胞生成。本文将讨论mirna在胶质瘤中的生物学功能及其在提高胶质瘤临床诊断、预测预后和抗胶质瘤治疗方面的意义。
Glioma represents a serious health problem worldwide. Despite advances in surgery, radiotherapy, chemotherapy, and targeting therapy, the disease remains one of the most lethal malignancies in humans, and new approaches to improvement of the efficacy of anti-glioma treatments are urgently needed. Thus, new therapeutic targets and tools should be developed based on a better understanding of the molecular pathogenesis of glioma. In this context, microRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in the development of the malignant phenotype of glioma cells, including cell survival, proliferation, differentiation, tumor angiogenesis, and stem cell generation. This review will discuss the biological functions of miRNAs in human glioma and their implications in improving clinical diagnosis, prediction of prognosis, and anti-glioma therapy.