Occupational exposure to eight organic dusts and respiratory cancer among Finns
Occupational exposure to eight organic dusts and respiratory cancer among Finns
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DOI：
10.1136/oem.2005.025825
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发表时间：
2006-11-01
影响因子：
4.9
通讯作者：
Pukkala, E. I.
中科院分区：
文献类型：
--
作者：
Laakkonen, A.;Kyyronen, P.;Pukkala, E. I.
背景资料：有关于癌症风险的有机dusts.Aim：致癌暴露主要是吸入性的，因此，作者研究了职业暴露于8种不同的有机dusts和呼吸道cancers in Finlands.Methods：作者随访了一个队列的所有经济活跃的芬兰人出生于1906年和1945年之间的3000万人年在1971-95年。通过与芬兰癌症登记处的记录联系，确定了鼻、喉、肺癌和间皮瘤的发病病例。1970年人口普查中的职业暴露被转换为8种有机粉尘的职业暴露矩阵（FINJEM）。累积暴露（CE）计算为患病率、水平和估计暴露持续时间的乘积。标准化发病率比（SIR）和95%的置信区间（CI）调整年龄，时期，和社会阶层的计算为每个有机粉尘使用的经济活动人口作为reference.Results：共观察到20 426例呼吸道癌症的发病病例。在暴露于木尘的男性中观察到患鼻癌的风险略有增加（SIR 1.42，95% CI 0.79至2.44）。对于喉癌，暴露于植物粉尘（主要是谷物米莱尔）的男性在高暴露等级中SIR升高（SIR 3.55，95%CI 1.30至7.72）。暴露于木尘的男性患肺癌的SIR升高，但仅在低暴露类别中（SIR 1.11，95% CI 1.04至1.18）。暴露于木尘的妇女表现出增加的SIR间皮瘤在低曝光类（SIR 4.57，95%CI 1.25至11.7）和一些多余的中等曝光category.Conclusions：暴露于有机粉尘是不太可能是呼吸道癌症的主要危险因素。即使是在芬兰主要接触的木尘，对鼻癌的影响也很小。作者发现了暴露于谷物粉尘可能增加喉癌风险的暗示性证据，并支持了暴露于纺织品粉尘以及植物和动物粉尘（农业粉尘）可能降低肺癌风险的假设。
Background: There is inconclusive evidence concerning cancer risks of organic dusts.Aim: The carcinogenic exposures are mainly inhalatory and the authors therefore studied associations between occupational exposure to eight different organic dusts and respiratory cancers in Finland.Methods: The authors followed up a cohort of all economically active Finns born between 1906 and 1945 for 30 million person-years during 1971-95. Incident cases of nasal, laryngeal, and lung cancer and mesotheliomas were identified through a record linkage with the Finnish Cancer Registry. Occupations from the population census in 1970 were converted to exposures to eight organic dusts with a job-exposure matrix (FINJEM). Cumulative exposure (CE) was calculated as a product of prevalence, level, and estimated duration of exposure. Standardised incidence ratios ( SIR) and 95% confidence intervals (CI) adjusted for age, period, and social class were calculated for each organic dust using the economically active population as the reference.Results: A total of 20 426 incident cases of respiratory cancer were observed. Slightly increased risk was observed among men exposed to wood dust for nasal cancer ( SIR 1.42, 95% CI 0.79 to 2.44). For laryngeal cancer, men exposed to plant dust (mainly grain millers) had a raised SIR in the high exposure class (SIR 3.55, 95% CI 1.30 to 7.72). Men exposed to wood dust had a raised SIR for lung cancer, but only in the low exposure class (SIR 1.11, 95% CI 1.04 to 1.18). Women exposed to wood dust showed an increased SIR for mesotheliomas in the low exposure class (SIR 4.57, 95% CI 1.25 to 11.7) and some excess in the medium exposure category.Conclusions: Exposure to organic dusts is unlikely to be a major risk factor of respiratory cancer. Even exposure to wood dust which is a major exposure in Finland seems to have minor effect for nasal cancer. The authors found suggestive evidence that exposure to grain dust may increase the risk of laryngeal cancer, and some support to the hypothesis that exposure to textile dust, and to plant and animal dust ( agricultural dusts) may decrease the risk of lung cancer.