Inverse Association of Plasma IgG Antibody to Aggregatibacter actinomycetemcomitans and High C-Reactive Protein Levels in Patients with Metabolic Syndrome and Periodontitis.
Inverse Association of Plasma IgG Antibody to Aggregatibacter actinomycetemcomitans and High C-Reactive Protein Levels in Patients with Metabolic Syndrome and Periodontitis.
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DOI：
10.1371/journal.pone.0148638
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Izumi Y
中科院分区：
文献类型：
--
作者：
Thanakun S;Pornprasertsuk-Damrongsri S;Gokyu M;Kobayashi H;Izumi Y
临床诊断的牙周炎，一种常见的慢性口腔感染，和代谢综合征之间的关联先前已被报道。本研究的目的是调查血浆IgG水平对Aggregatibacteractinomycetemcomitans，牙龈卟啉单胞菌，中间普氏菌，C-反应蛋白，牙周状况与代谢综合征的关联。采用酶联免疫吸附法检测血浆IgG和C反应蛋白水平，并检测唾液中A。用实时定量聚合酶链反应测定伴放线菌和牙龈卟啉单胞菌。在127名35-76岁的个体中，57名参与者患有代谢综合征和重度牙周炎，25名患有代谢综合征但没有重度牙周炎，17名健康个体患有重度牙周炎，28名健康个体没有重度牙周炎。代谢综合征患者对A.与健康参与者相比，无论唾液水平或牙周炎状态如何，放线菌伴放线菌（p = 0.008）。无论唾液水平或参与者的健康状况如何，严重牙周炎患者对牙龈卟啉单胞菌的IgG抗体应答均显着较高（p<0.001）。血浆IgG滴度为中间变形杆菌不一致的代谢综合征或牙周参与者。我们的研究结果表明，存在较低水平的IgG抗体的A。actinomycetemcomitans（OR = 0.1; 95%CI 0.0-0.7），但不是牙龈卟啉单胞菌，一种严重的牙周炎状态（OR = 7.8; 95%CI 1.1-57.0），高C反应蛋白水平（OR = 9.4; 95%CI 1.0-88.2）和体重指数（OR = 3.0; 95%CI 1.7-5.2）与代谢综合征的存在相关。IgG抗体应答降低在抗A.伴随放线菌，增加C-反应蛋白水平之间的关联牙周疾病和代谢综合征在一组泰国患者的建议。
The association between clinically diagnosed periodontitis, a common chronic oral infection, and metabolic syndrome has been previously reported. The aim of this study was to investigate the association of plasma IgG levels against Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Prevotella intermedia, C-reactive protein, and periodontal status with metabolic syndrome. Plasma IgG levels and C-reactive protein were measured by enzyme-linked immunosorbent assay, and salivary levels of A. actinomycetemcomitans and P. gingivalis were determined by quantitative real-time polymerase chain reaction. Among 127 individuals aged 35–76 years, 57 participants had metabolic syndrome and severe periodontitis, 25 had metabolic syndrome and an absence of severe periodontitis, 17 healthy individuals had severe periodontitis, and 28 healthy individuals were without severe periodontitis. Patients with metabolic syndrome had reduced humoral immune response to A. actinomycetemcomitans (p = 0.008), regardless of their salivary levels or periodontitis status compared with healthy participants. The IgG antibody response to P. gingivalis, regardless of their salivary levels or participants’ health condition, was significantly higher in severe periodontitis patients (p<0.001). Plasma IgG titers for P. intermedia were inconsistent among metabolic syndrome or periodontal participants. Our results indicate that the presence of lower levels of IgG antibodies to A. actinomycetemcomitans (OR = 0.1; 95%CI 0.0–0.7), but not P. gingivalis, a severe periodontitis status (OR = 7.8; 95%CI 1.1–57.0), high C-reactive protein levels (OR = 9.4; 95%CI 1.0–88.2) and body mass index (OR = 3.0; 95%CI 1.7–5.2), are associated with the presence of metabolic syndrome. The role of the decreased IgG antibody response to A. actinomycetemcomitans, increased C-reactive protein levels on the association between periodontal disease and metabolic syndrome in a group of Thai patients is suggested.