Serum vitamin D concentration status and its correlation with early biomarkers of remodeling following acute myocardial infarction
Serum vitamin D concentration status and its correlation with early biomarkers of remodeling following acute myocardial infarction
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DOI：
10.1007/s00392-011-0394-0
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发表时间：
2012-05-01
影响因子：
5
通讯作者：
Salarifar, Mojtaba
中科院分区：
文献类型：
--
作者：
Khalili, Hossein;Talasaz, Azita Hajhossein;Salarifar, Mojtaba
低水平的血清维生素D被证明与心血管疾病以及糖尿病、血脂异常和高血压的存在有关。维生素D缺乏是一个全球性的问题，也是伊朗的问题。据我们所知，这是第一项关于急性心肌梗死的研究，评估维生素D水平与住院患者预后的相关性，特别是在心肌重构的早期生物标志物方面。在一项前瞻性研究中，纳入了急性ST段抬高心肌梗死患者。确定了患者的25(OH)D水平，并研究了其与临床特征的关系，包括早期重塑生物标志物和住院结果。在纳入的139名患者中，80.5%是男性。72.7%的患者存在25(OH)缺乏。高血压和心血管用药史分别是低维生素D水平的危险因素(OR=2.92，CI=1.34~6.37，P<0.05)和(OR=2.36，CI=1.05~5.29，P<0.05)。此外，住院患者的存活率与维生素D浓度呈显著正相关(P<；0.001)。经多因素分析发现，急性心肌梗死后72 h血浆25(OH)D水平与基质金属蛋白酶-9水平呈显著负相关(P=0.011)，作为早期重构指标的血清基质金属蛋白酶-9水平与25(OH)D水平呈显著负相关。此外，在这项研究中，低水平的维生素D与患者的死亡率有关。
Low serum level of vitamin D was shown to be associated with cardiovascular diseases as well as the presence of diabetes, dyslipidemia, and hypertension. Vitamin D deficiency is a global problem, and is an Iranian problem as well. To the best of our knowledge, this was the first study on acute myocardial infarction that evaluates the correlation of vitamin D level with inpatients' outcomes, particularly on the early biomarkers of myocardial remodeling.In a prospective study, patients with acute ST segment elevation myocardial infarction were included. The patients' 25 (OH) D levels were identified and the associations with clinical characteristics, including early remodeling biomarkers and in-hospital outcomes, were investigated.From the 139 included patients, 80.5% were male. The 25 (OH) deficiency was present in 72.7% of the patients. Hypertension and positive history of cardiovascular drug use were risk factors for the presence of low vitamin D levels (OR = 2.92; CI = 1.34-6.37, P < 0.05) and (OR = 2.36; CI = 1.05-5.29, P < 0.05), respectively. Moreover, a significant positive relationship between the inpatients' survival and the concentration of vitamin D was present (P < 0.001). By performing a multivariate analysis, we found that there was a significant inverse relationship between the level of 25 (OH) D and the level of MMP-9 after 72 h (P = 0.011).The results of our study revealed a significant inverse relationship between serum MMP-9 as a biomarker of early remodeling and the level of 25(OH) D in patients after an acute myocardial infarction. Moreover, low level of vitamin D was associated with patients' mortality in this study.