Post-Traumatic, Drug-Resistant Epilepsy and Review of Seizure Control Outcomes from Blinded, Randomized Controlled Trials of Brain Stimulation Treatments for Drug-Resistant Epilepsy.
Post-Traumatic, Drug-Resistant Epilepsy and Review of Seizure Control Outcomes from Blinded, Randomized Controlled Trials of Brain Stimulation Treatments for Drug-Resistant Epilepsy.
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DOI：
10.7759/cureus.744
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发表时间：
2016-08-22
期刊：
影响因子：
--
通讯作者：
Levine ZT
中科院分区：
文献类型：
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作者：
Larkin M;Meyer RM;Szuflita NS;Severson MA;Levine ZT
背景：许多创伤后癫痫（PTE）患者对药物产生耐药性。神经刺激作为耐药性癫痫（DRE）的治疗方法是临床研究的一个活跃领域。目的：总结DRE患者中选定的有创脑刺激（IBS）和无创脑刺激（NIBS）治疗选项的设盲随机对照试验（RCT）的方法、报告的癫痫控制结局指标和不良事件。方法：使用与感兴趣主题相关的检索词检索PubMed 1995-2014年的文章。识别报告关注结局的可用相关文章并提取数据。还参考了相关文章参考文献列表中的文章和clinicaltrials.gov。结果：分析了11篇文章，共识别出795例患者。研究表明，选择神经刺激治疗显着降低癫痫发作频率的DRE患者。
Background: Many post-traumatic epilepsy (PTE) patients become resistant to medications. Nervous stimulation as a treatment for drug-resistant epilepsy (DRE) is an active area of clinical investigation. Objective: To summarize methods, reported seizure control outcome measures, and adverse events from blinded, randomized control trials (RCTs) for selected invasive brain stimulation (IBS) and non-invasive brain stimulation (NIBS) treatment options in patients with DRE. Methods: PubMed was searched for articles from 1995-2014, using search terms related to the topics of interest. Available relevant articles reporting the outcomes of interest were identified and data was extracted. Articles in the reference lists of relevant articles and clinicaltrials.gov were also referenced. Results: Eleven articles were analyzed with a total of 795 patients identified. Studies showed that select nervous stimulation treatments significantly reduced seizure frequency in patients with DRE.