Comparison of 11C-choline PET and FDG PET for the differential diagnosis of malignant tumors
Comparison of 11C-choline PET and FDG PET for the differential diagnosis of malignant tumors
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DOI：
10.1007/s00259-004-1496-y
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发表时间：
2004-08-01
影响因子：
9.1
通讯作者：
Endo, K
中科院分区：
文献类型：
--
作者：
Tian, M;Zhang, H;Endo, K
我们前瞻性地评估并比较了c -11-胆碱正电子发射断层扫描（PET）与[F-18]-2-氟-2-脱氧-d -葡萄糖（FDG） PET在良恶性肿瘤鉴别中的作用。共纳入126例患者130个病灶，其中脑肿瘤25例，头颈部肿瘤51例，骨肿瘤15例，肺肿瘤16例，软组织肿瘤23例。c -11-胆碱PET和FDG PET分别在注射275-370 MBq示踪剂后5分钟和40分钟进行。采用标准化摄取值（SUV）评估PET数据，并根据病理数据进行分析。恶性肿瘤的c -11-胆碱摄取为3.9 +/- 2.3 (n=81)，显著高于良性病变（n=49） （2.6 +/- 1.7）
We prospectively assessed and compared the usefulness of C-11-choline positron emission tomography (PET) with that of [F-18]-2-fluoro-2-deoxy-D-glucose (FDG) PET for the differentiation between benign and malignant tumors. A total of 126 patients with 130 lesions were studied (25 brain tumors, 51 head and neck tumors, 15 bone tumors, 16 lung tumors, and 23 soft tissue tumors). C-11-choline PET and FDG PET were performed from 5 and 40 min, respectively, after injection of 275-370 MBq tracer. PET data were evaluated using the standardized uptake value (SUV) and were analyzed in accordance with the pathologic data. The C-11-choline uptake in malignancies was 3.9 +/- 2.3 (n=81), which was significantly higher than that in benign lesions (n=49) (2.6 +/- 1.7, P