Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells.
Immunomodulatory effects of deacetylase inhibitors: therapeutic targeting of FOXP3+ regulatory T cells.
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DOI：
10.1038/nrd3031
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发表时间：
2009-12
影响因子：
120.1
通讯作者：
Hancock, Wayne W.
中科院分区：
文献类型：
--
作者：
Wang, Liqing;de Zoeten, Edwin F.;Greene, Mark I.;Hancock, Wayne W.
经典的锌依赖组蛋白脱乙酰酶(HDAC)催化从组蛋白尾部和许多非组蛋白蛋白中去除乙酰基，包括转录因子FOXP3，它是调节性T细胞发育和功能的关键调节因子。许多HDAC抑制剂正在进行癌症临床试验，但一部分HDAC抑制剂具有重要的抗炎或免疫抑制作用，可能对免疫性炎症疾病或移植后有治疗作用。这些效应中至少有一部分是由于HDAC抑制剂能够增强FOXP3+调节性T细胞的产生和抑制功能。了解哪些HDAC有助于调节调节性T细胞的功能，可能会进一步刺激新的类别或亚类特异性的HDAC抑制剂的开发，其应用超出了肿瘤学的范畴。
Classical zinc-dependent histone deacetylases (HDACs) catalyse the removal of acetyl groups from histone tails and also from many non-histone proteins, including the transcription factor FOXP3, a key regulator of the development and function of regulatory T cells. Many HDAC inhibitors are in cancer clinical trials, but a subset of HDAC inhibitors has important anti-inflammatory or immunosuppressive effects that might be of therapeutic benefit in immuno-inflammatory disorders or post-transplantation. At least some of these effects result from the ability of HDAC inhibitors to enhance the production and suppressive functions of FOXP3+ regulatory T cells. Understanding which HDACs contribute to the regulation of the functions of regulatory T cells may further stimulate the development of new class- or subclass-specific HDAC inhibitors with applications beyond oncology.
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影响因子：
20.3
作者：
Borsellino, Giovanna;Kleinewietfeld, Markus;Falk, Kirsten
通讯作者：
Falk, Kirsten
DOI：
10.1165/rcmb.2008-0255oc
发表时间：
2009-04-01
影响因子：
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作者：
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作者：
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影响因子：
82.9
作者：
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通讯作者：
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