Two new diterpenoids fromPenicillium chrysogenumMT-12, an endophytic fungus isolated fromHuperzia serrata
Two new diterpenoids fromPenicillium chrysogenumMT-12, an endophytic fungus isolated fromHuperzia serrata
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DOI：
10.1080/14786419.2020.1808637
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发表时间：
2020-08-19
影响因子：
2.2
通讯作者：
Shi, She-Po
中科院分区：
文献类型：
--
作者：
Qi, Bowen;Jia, Fangfang;Shi, She-Po
从药用植物蛇足石杉（Huperzia serrata）的内生真菌产黄青霉（Penicillium chrysogenum MT-12）的固体发酵液中分离得到两个新的二萜类化合物，分别命名为Penicichrysogene A（1）和Penicichrysogene B（2）。根据大量的光谱和光谱数据（1D和2D NMR，UV，IR和HRESIMS）对其结构进行了解析。根据实验和计算的电子圆二色光谱，对1和2的绝对构型进行了归属。化合物1对凝血酶活化的血小板的ATP释放具有抑制活性，IC 50 = 42.7 ± 3.5 μ M。
Two new diterpenoids, penicichrysogene A (1) and penicichrysogene B (2), were isolated from the solid substrate fermentation cultures ofPenicillium chrysogenumMT-12, an endophytic fungus isolated from the medicinal plant ofHuperzia serrata. Their structures were elucidated on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR, UV, IR, and HRESIMS). The absolute configurations of1and2were assigned on the basis of experimental and calculated electronic circular dichroism spectra. Compound1exhibited inhibitory activity on ATP release of thrombin-activated platelets with IC50= 42.7 +/- 3.5 mu M.