The Yugoslavia Prospective Lead Study: contributions of prenatal and postnatal lead exposure to early intelligence
The Yugoslavia Prospective Lead Study: contributions of prenatal and postnatal lead exposure to early intelligence
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DOI：
10.1016/s0892-0362(00)00106-9
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发表时间：
2000-11-01
影响因子：
2.9
通讯作者：
Graziano, JH
中科院分区：
文献类型：
--
作者：
Wasserman, GA;Liu, X;Graziano, JH
为了调查铅暴露时间与早期智力之间的关系，我们检查了3、4、5和7岁时的心理测量评估结果，这些儿童的母亲是从南斯拉夫的一个冶炼厂城镇和一个非铅暴露城镇招募的。我们比较了产前血铅(BPB)和出生后早期(0-2年)或后期(从2年起)BPB对儿童智力的相对贡献，纵向测量的时间为3岁和4岁(McCarthy GCI)，5岁(韦氏学龄前和小学智商修订版，WPPSI-R智商)和7岁(韦氏儿童智力量表-ITT版，WISC-III智商)，控制因素：家庭环境质量观察；母亲的年龄、智力、教育和种族；以及出生体重和性别。出生前和出生后BPB的升高都与幼儿智力的小幅下降有关。(C)2000 Elsevier Science Inc.保留所有权利。
To investigate associations between the timing of lead (Pb) exposure on early intelligence, we examined the results of psychometric evaluations at ages 3, 4, 5, and 7 years, from 442 children whose mothers were recruited during pregnancy from a smelter town and a non-lead-exposed town in Yugoslavia. We compared the relative contribution of prenatal blood lead (BPb) with that of relative increases in BPb in either the early (0-2 years) or the later (from 2 years on) postnatal period to child intelligence measured longitudinally at ages 3 and 4 (McCarthy GCI), 5 (Wechsler Preschool and Primary Scale of Intelligence-Revised, WPPSI-R IQ), and 7 (Wechsler Intelligence Scale for Children-version ITT, WISC-III IQ), controlling for: Home Observation for Measurement of the Environment (HOME) quality; maternal age, intelligence, education, and ethnicity; and birthweight and gender. Elevations in both prenatal and postnatal BPb were associated with small decrements in young children's intelligence. (C) 2000 Elsevier Science Inc. All rights reserved.