Glutamate Receptor-Mediated Ischemic Injury of Premyelinated Central Axons
Glutamate Receptor-Mediated Ischemic Injury of Premyelinated Central Axons
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DOI：
10.1002/ana.21767
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发表时间：
2009-11-01
影响因子：
11.2
通讯作者：
Fern, Robert
中科院分区：
文献类型：
--
作者：
Alix, James J. P.;Fern, Robert
目的：轴突缺血性损伤是脑室周围白质软化的一个特征，脑室周围白质软化是脑瘫的一种病理相关表现。近期有证据表明，轴突在获得第一层致密髓鞘之前就已受损。在此我们研究未髓鞘化的中枢轴突发生缺血性损伤的细胞机制。
方法：出生后第10天（P10）大鼠视神经中三分之二的轴突是细小的未髓鞘化轴突（
Objective: Ischemic injury of axons is a feature of periventricular leukomalacia, a pathological correlate of cerebral palsy. Recent evidence suggests that axons are damaged before they receive the first layer of compact myelin. Here we examine the cellular mechanisms underlying ischemic-type injury of premyelinated central axons.Methods: Two-thirds of axons in the postnatal day 10 (P10) rat optic nerve are small premyelinated axons (