Allergy and the risk of selected digestive and laryngeal neoplasms
Allergy and the risk of selected digestive and laryngeal neoplasms
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DOI：
10.1097/01.cej.0000130016.85687.cf
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发表时间：
2004-06-01
影响因子：
2.4
通讯作者：
La Vecchia, C
中科院分区：
文献类型：
--
作者：
Bosetti, C;Talamini, R;La Vecchia, C
自20世纪90年代初以来，意大利开展了一系列关于消化道和喉部肿瘤的病例对照研究，对过敏和癌症之间的关系进行了研究。这些患者包括598例突发事件、组织学证实的口腔和咽癌、304例食道癌、1225例结肠、728例直肠、460例喉癌和4999例对照，这些患者与急性非肿瘤性疾病患者在同一医院网络中入院。所有被检查的癌症部位与过敏史呈负相关(口腔和咽部的优势比为0.44，食道的优势比为0.80，结肠的优势比为0.76，直肠的优势比为0.54，喉部的优势比为0.33)。在年龄和性别的层次上，以及在癌症诊断或入院前5年或更长时间首次诊断为过敏的受试者被考虑时，这些相关性是一致的。因此，本研究为既往过敏史对癌症风险的可能保护作用提供了进一步的证据。(C)2004年，里平科特·威廉姆斯·威尔金斯。
The relation between allergy and cancer has been investigated within an integrated series of case-control studies of digestive tract and laryngeal neoplasms conducted in Italy since the early 1990s. These included 598 patients with incident, histologically confirmed cancer of the oral cavity and pharynx, 304 of the oesophagus, 1225 of the colon, 728 of the rectum, 460 of the larynx and 4999 controls, selected among patients admitted to the same network of hospitals as cases for acute, non-neoplastic diseases. Inverse associations with history of allergy were found for all cancer sites examined (odds ratio=0.44 for oral cavity and pharynx, 0.80 for oesophagus, 0.76 for colon, 0.54 for rectum and 0.33 for larynx). The associations were consistent in strata of age and sex, and when subjects with a first diagnosis of allergy 5 or more years before cancer diagnosis or hospital admission were considered. The present study therefore provides further evidence for a possible protective effect of prior history of allergy on cancer risk. (C) 2004 Lippincott Williams Wilkins.