PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY IN 47 HIV-SEROPOSITIVE PATIENTS - NEUROIMAGING WITH CLINICAL AND PATHOLOGICAL CORRELATION
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY IN 47 HIV-SEROPOSITIVE PATIENTS - NEUROIMAGING WITH CLINICAL AND PATHOLOGICAL CORRELATION
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DOI：
10.1148/radiology.187.1.8451420
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发表时间：
1993-04-01
期刊：
影响因子：
19.7
通讯作者：
LIMONTE, LP
中科院分区：
文献类型：
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作者：
WHITEMAN, MLH;POST, MJD;LIMONTE, LP
作者研究了一个大系列（n = 47）的人类免疫缺陷病毒（HIV）1血清阳性患者的放射学表现谱，并经病理证实为进行性多灶性白质脑病，以确定该疾病的特征性影像学模式。回顾性分析了47例患者的36例计算机断层扫描（CT）和29例磁共振（MR）成像研究，并与病理和临床结果进行了相关分析。在32例CT检查和13例MR成像研究中使用了造影剂。病变在CT扫描上通常呈低密度，在双回波MR图像上以信号强度增加而无肿块效应为特征。病变最常累及顶枕叶或额叶的脑室周围和皮质下白色物质。15例患者有后颅窝病变，2例疾病仅限于后颅窝。胼胝体（7例患者）、丘脑（8例患者）和基底节（7例患者）也有病变。与CT相比，MRI对病变的范围和数量表现出更高的敏感性。
The authors investigated the spectrum of radiologic findings in a large series (n = 47) of patients seropositive to human immunodeficiency virus (HIV) 1 and with pathologically proved progressive multifocal leukoencephalopathy, to determine the characteristic imaging pattern of the disease. Thirty-six computed tomographic (CT) scans and 29 magnetic resonance (MR) imaging studies obtained in the 47 patients were retrospectively reviewed and correlated with pathologic and clinical findings. Contrast agents were used in 32 CT procedures and 13 MR imaging studies. Lesions typically were hypoattenuating on CT scans and were characterized by areas of increased signal intensity without mass effect on dual-echo MR images. Lesions most often involved periventricular and subcortical white matter in parietooccipital or frontal lobes. Fifteen patients had posterior fossa lesions, and disease was limited to the posterior fossa in two. Lesions were also in the corpus callosum (seven patients), thalamus (eight patients), and basal ganglia (seven patients). In comparison with CT, MR imaging demonstrated greater sensitivity for the extent and number of lesions.