Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat
Goal-directed whisking increases phase-locking between vibrissa movement and electrical activity in primary sensory cortex in rat
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DOI：
10.1073/pnas.0308470101
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发表时间：
2004-08-17
影响因子：
11.1
通讯作者：
Kleinfeld, D
中科院分区：
文献类型：
--
作者：
Ganguly, K;Kleinfeld, D
我们测试的假设，即行为背景调制锁相之间的节奏运动活动和伴随的电活动在初级感觉（S1）皮层。我们使用大鼠探索性搅拌作为模型系统，并记录两个测量：（i）作为触须位置的替代物的肌电肌电图（delEMG），和（ii）作为电活动的指标的S1皮层的场电位（delLFP）。delEMG和delLFP相位锁定的程度进行了比较，为三个类别的节奏搅拌：（i）寻找一个物体与触须的食物奖励，（ii）在空气中搅拌的目标返回到家庭笼，和（iii）搅拌没有奖励。我们观察到，相位锁定的幅度几乎是三倍的两个奖励条件相比，无奖励搅拌。关键的是，增加锁定并不伴随着奖励任务的皮质delLFP振幅的增加。额外的实验表明，在S1皮层中的感觉诱发反应的幅度与搅拌期间delEMG和delLFP之间的锁定幅度之间没有显著关系。我们的结论是，一个搅拌任务的行为背景下，可以增加调制的S1皮层活动的运动输出，而不伴随着活动的幅度增加。
We tested the hypothesis that behavioral context modulates phase-locking between rhythmic motor activity and concomitant electrical activity induced in primary sensory (S1) cortex. We used exploratory whisking by rat as a model system and recorded two measures: (i) the mystacial electromyogram (delEMG) as a surrogate of vibrissa position, and (ii) the field potential (delLFP) in S1 cortex as an indicator of electrical activity. The degree to which the delEMG and delLFP were phase-locked was compared for three categories of rhythmic whisking: (i) searching for an object with the vibrissae for a food reward, (ii) whisking in air for the goal of returning to the home cage, and (iii) whisking with no reward. We observed that the magnitude of phase-locking was nearly tripled for the two rewarded conditions compared to unrewarded whisking. Critically, increased locking was not accompanied by an increase in the amplitude of the cortical delLFP for the rewarded tasks. Additional experiments showed that there was no significant relation between the amplitude of a sensory-evoked response in S1 cortex and the magnitude of the locking between the delEMG and the delLFP during whisking. We conclude that the behavioral context of a whisking task can increase the modulation of S1 cortical activity by motor output without a concomitant increase in the magnitude of activity.