ConSurf: Identification of Functional Regions in Proteins by Surface-Mapping of Phylogenetic Information
ConSurf: Identification of Functional Regions in Proteins by Surface-Mapping of Phylogenetic Information
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DOI：
10.1093/bioinformatics/19.1.163
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发表时间：
2003-01-01
期刊：
影响因子：
5.8
通讯作者：
Ben-Tal, N
中科院分区：
文献类型：
--
作者：
Glaser, F;Pupko, T;Ben-Tal, N
我们最近开发了一种算法工具，通过估计氨基酸在其紧密序列同源物之间的保守程度来识别已知三维结构的蛋白质中的功能重要区域。将保守等级投影到这些蛋白质的分子表面，揭示了高度保守(或有时高度可变)残基的斑块，这些残基往往具有重要的生物学功能。我们提出了一个新的网络服务器，ConSurf，它自动化了这些算法工具。ConSurf可用于高通量鉴定蛋白质中的功能区。
We recently developed algorithmic tools for the identification of functionally important regions in proteins of known three dimensional structure by estimating the degree of conservation of the amino-acid sites among their close sequence homologues. Projecting the conservation grades onto the molecular surface of these proteins reveals patches of highly conserved (or occasionally highly variable) residues that are often of important biological function. We present a new web server, ConSurf, which automates these algorithmic tools. ConSurf may be used for high-throughput characterization of functional regions in proteins.