A longitudinal quantitative MRI study of community-based patients with chronic epilepsy and newly diagnosed seizures: Methodology and preliminary findings
A longitudinal quantitative MRI study of community-based patients with chronic epilepsy and newly diagnosed seizures: Methodology and preliminary findings
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DOI：
10.1006/nimg.2001.0773
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发表时间：
2001-07-01
期刊：
影响因子：
5.7
通讯作者：
Duncan, JS
中科院分区：
文献类型：
--
作者：
Liu, RSN;Lemieux, L;Duncan, JS
实验数据和人体数据表明，短暂反复发作的癫痫可能因累积效应导致进行性脑损伤。然而，针对这一基本问题的纵向研究却很缺乏。我们通过一项大型的前瞻性社区观察研究来满足这一需求，该研究旨在对154名慢性活动性癫痫患者和90名新诊断为癫痫发作的患者在间隔3.5年后进行再次扫描。在此，我们描述了用于识别海马体、小脑和新皮质结构随时间的细微体积变化的定量磁共振方法，并报告了初步研究结果。利用这种方法，我们先前已经表明，我们能够可靠地检测出个体海马体体积（HV）和小脑体积（CBV）分别大于3.1%和3.0%的变化（勒米厄等人，2000年）。对前53名受试者（24名慢性活动性癫痫患者、90名新诊断为癫痫发作的患者和20名对照者）的分析表明，有4个人的海马体体积显著减少。自动和半自动计算分别在2名、3名和1名受试者中检测到小脑体积、全脑体积和灰质体积显著减少。未检测到白质体积有显著减少。对整个队列进行再次扫描所收集的数据将有助于进一步提供关于反复发作的癫痫与继发性脑损伤之间关系的信息。（C）2001年学术出版社
Experimental and human data suggest that progressive cerebral damage may result from the cumulative effect of brief recurrent seizures. Longitudinal studies addressing this fundamental question, however, are lacking. We have addressed this need with a large prospective community-based observational study, which aims to rescan 154 patients with chronic active epilepsy and 90 patients with newly diagnosed seizures, after an interval of 3.5 years. Here, we describe the quantitative magnetic resonance methods used to identify subtle volume changes in hippocampal, cerebellar, and neocortical structures over time and report preliminary findings. Using this methodology, we have previously shown that we can reliably detect individual hippocampal volume (HV) and cerebellar volume (CBV) changes greater than 3.1 and 3.0%, respectively (Lemieux et al., 2000). Analysis of the first 53 subjects (24 patients with chronic active epilepsy, 90 patients with newly diagnosed seizures, and 20 controls) has demonstrated significant HV losses in 4 individuals. Automated and semiautomated calculation has detected significant reductions in CBV, total brain volume, and gray matter volume in 2, 3, and 1 subject, respectively. There were no significant white matter volume losses detected, Data collected from rescanning the entire cohorts will help to provide further information on the relationship between recurrent seizures and secondary brain damage. (C) 2001 Academic Press.