Reproductive and menopausal factors and risk of second primary breast cancer after in situ breast carcinoma.
Reproductive and menopausal factors and risk of second primary breast cancer after in situ breast carcinoma.
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生殖和绝经因素以及继原位乳腺癌之后第二原发性乳腺癌的风险。
DOI：
10.1007/s10552-018-1119-8
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Li,ChristopherI
中科院分区：
文献类型：
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作者：
Baglia,MichelleL;Tang,Mei-TzuC;Malone,KathleenE;Porter,Peggy;Li,ChristopherI
目的原位乳腺癌患者发生第二原发性乳腺癌的风险高于普通人群中的女性。我们有有限的理解，为什么一些妇女与以前的原位乳腺癌发展第二原发性乳腺癌，而其他人doesn 't.MethodsIn这个以人群为基础的巢式病例对照研究，我们评估了生殖和绝经因素之间的关联和风险发展第二原发性乳腺癌的妇女与以前的原位乳腺癌。使用条件Logistic回归分析，这些协会进行了评估，在552例和1032个单独匹配的controls.ResultsOlder年龄初潮与第二原发性乳腺癌的风险在妇女与以前的原位乳腺癌（与< 12岁相比，13岁：OR 0.60（0.42，0.85）; ≥ 14岁：OR 0.69（0.47，1.00）; P趋势= 0.07）。母乳喂养> 12个月与发生第二原发性乳腺癌的风险降低相关（OR 0.62（0.39，0.98））。没有协会观察到其他生殖或绝经因素evaluated.ConclusionsResults从这项研究表明，生殖因素可能发挥作用，在发展中的第二原发性乳腺癌诊断后，原位乳腺癌。
PurposeIn situ breast cancer patients have a higher risk of developing a second primary breast cancer than women in the general population have of developing breast cancer. We have limited understanding of why some women with a previous in situ breast cancer develop second primary breast cancers while others do not.MethodsIn this population-based nested case–control study, we evaluated the association between reproductive and menopausal factors and risk of developing a second primary breast cancer among women with a previous in situ breast cancer. Using conditional logistic regression, these associations were evaluated in 552 cases and 1032 individually matched controls.ResultsOlder age at menarche was associated with risk of second primary breast cancer among women with a previous in situ breast cancer (compared to age < 12, age 13: OR 0.60 (0.42, 0.85); age ≥ 14: OR 0.69 (0.47, 1.00);Ptrend= 0.07). Breastfeeding for > 12 months was associated with a decreased risk of developing a second primary breast cancer (OR 0.62 (0.39, 0.98)). No associations were observed for other reproductive or menopausal factors evaluated.ConclusionsResults from this study suggest that reproductive factors may play a role in development of a second primary breast cancer after diagnosis of in situ breast carcinoma.