sorLA: sorting out APP.
sorLA: sorting out APP.
复制标题
sorLA：整理APP。
作者：
Sanjiv J. Shah;Gang Yu
淀粉样β蛋白多肽在大脑中的积累是阿尔茨海默病的主要因素。蛋白水解性分泌酶是淀粉样β多肽产生的中心，近年来，它已成为药物发现的重要靶点。新发表的结果表明，分类蛋白相关受体SorLA/LR11调控淀粉样β蛋白前体的加工和运输，为开发阿尔茨海默病的分子临床治疗化合物提供了一个替代靶点。
The accumulation of amyloid-beta peptides in the brain is a major factor of Alzheimer Disease. Central to the production of the amyloid-beta peptides are the proteolytic secretases, which, recently, have been important targets of drug discovery. Newly published results indicate that the sorting protein-related receptor sorLA/LR11 regulates processing and trafficking of the precursor of the amyloid-beta peptides, revealing an alternative target for developing molecular clinical therapeutic compounds for Alzheimer Disease.