Epithelial-mesenchymal transition and cancermetastasis
Epithelial-mesenchymal transition and cancermetastasis
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DOI：
10.1007/s10330-011-0740-8
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Junjian Deng;Ximing Xu
中科院分区：
文献类型：
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作者：
Junjian Deng;Ximing Xu
上皮-间质转化（Epithelial-mesenchymal transition，EMT）最初被认为是哺乳动物胚胎发生过程中的一种生理现象，是维持机体生命稳定的基本生物学事件。近年来的研究表明，EMT在多种肿瘤的发生、发展过程中起着重要作用，是上皮性肿瘤侵袭和转移的重要途径。EMT过程中细胞特性发生改变，细胞失去细胞间、细胞间基质间的相互作用，失去顶端极性，细胞骨架发生重组，变得孤立、有运动能力，并对失巢凋亡具有抵抗力，进而成为梭形间充质细胞。本文着重从EMT的细胞形态发生、标志物及分子机制调控等方面进行综述，探讨EMT与肿瘤发生、转移的关系。
Epithelial-mesenchymal transition (EMT) is initially considered as a physiological phenomenon during the embryogenesis of mammals, as well as a basic biological event maintaining the stability of the vital body. Recent researches indicated that EMT plays a critical role in various tumors progression, through which epithelial cancers invade and metastasize. The cell characteristics are changed during EMT, in which the cells lose cell-cell and cell-matrix interactions and apical polarity, reorganize their cytoskeleton, and become isolated, motile, as well as resistant to anoikis, then become spindle-shaped mesenchymal cells. This review lays emphasis on studying the cell morphogenesis, makers and molecular mechanism regulation about EMT, discussing the relationship between the EMT and the cancer development and metastasis.