Cardiac Strain in a Swine Model of Regional Hibernating Myocardium: Effects of CoQ10 on Contractile Reserve Following Bypass Surgery.
Cardiac Strain in a Swine Model of Regional Hibernating Myocardium: Effects of CoQ10 on Contractile Reserve Following Bypass Surgery.
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猪区域冬眠心肌模型中的心脏应变：CoQ10 对搭桥手术后收缩储备的影响。
DOI：
10.1007/s12265-016-9696-y
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发表时间：
2016
影响因子：
3.4
通讯作者：
McFalls,EdwardO
中科院分区：
文献类型：
--
作者：
HocumStone,Laura;Butterick,TammyA;Duffy,Cayla;Swingen,Corey;Ward,HerbertB;Kelly,RosemaryF;McFalls,EdwardO
辅酶Q10(CoQ10)是否能改善冠状动脉搭桥术(CABG)后的功能，临床证据相互矛盾。采用猪冬眠心肌模型，在冠状动脉旁路移植术后4周，通过磁共振成像检测每日辅酶Q10对心肌收缩功能的改善作用。12头猪接受了开胸手术，并在左前降支(LAD)上放置了一条缩窄器。在12周时，他们接受了非体外循环搭桥，并每天接受辅酶Q10(10 mg/kg/天)或安慰剂的膳食补充剂。在冠状动脉搭桥术后4周，安慰剂组和辅酶Q10组冬眠LAD区域的周向应变测量没有差异，多巴酚丁胺增加的程度相似(分别为−14.7 ± 0.6和−14.8 ± 0.1(NS))。处死后，安慰剂组大鼠线粒体分离株和蛋白质羰基均有氧化应激标记，辅酶Q10组分别为6.14 ± 0.36和5.05 ± 0.32nmoL/mg(NS)。综上所述，在CABG术后4周，辅酶Q10并没有改善收缩储备或减轻氧化应激。
There is conflicting clinical evidence whether administration of coenzyme Q10 (CoQ10) improves function following coronary artery bypass graft surgery (CABG). Using a swine model of hibernating myocardium, we tested whether daily CoQ10 would improve contractile function by MRI at 4-week post-CABG. Twelve pigs underwent a thoracotomy and had a constrictor placed on the left anterior descending (LAD). At 12 weeks, they underwent off-pump bypass and received daily dietary supplements of either CoQ10 (10 mg/kg/day) or placebo. At 4-week post-CABG, circumferential strain measurements in the hibernating LAD region from placebo and CoQ10 groups were not different and increased to a similar extent with dobutamine (−14.7 ± 0.6 versus −14.8 ± 0.1, respectively (NS)). Post-sacrifice, oxidant stress markers were obtained in the mitochondrial isolates and protein carbonyl in the placebo, and CoQ10 groups were 6.14 ± 0.36 and 5.05 ± 0.32 nmol/mg, respectively (NS). In summary, CoQ10 did not improve contractile reserve or reduce oxidant stress at 4-week post-CABG.