THE STRUCTURES AND STEREOCHEMISTRY OF CYTOTOXIC SESQUITERPENE QUINONES FROM DACTYLOSPONGIA-ELEGANS
THE STRUCTURES AND STEREOCHEMISTRY OF CYTOTOXIC SESQUITERPENE QUINONES FROM DACTYLOSPONGIA-ELEGANS
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DOI：
10.1016/s0040-4020(01)80012-0
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发表时间：
1992-08-07
期刊：
影响因子：
2.1
通讯作者：
CREWS, P
中科院分区：
文献类型：
--
作者：
RODRIGUEZ, J;QUINOA, E;CREWS, P
线虫粗提物的细胞毒性激发了对活性成分的探索。阐明了四个新化合物的结构和绝对立体化学。 9、11、18、19.和十三种先前描述的化合物3、4、6a。 7、8、10、12 - 17、21。这些化合物是从三个不同印度-太平洋地区的线虫集合中分离出来的。斐济。巴布亚新几内亚和泰国。与其他海绵或海藻相比，该物种似乎阐述了更广泛的混合生物发生倍半萜-氢醌（-醌）代谢物。三种化合物 4、9 和 13 是有效的（IC50 小于 1-mu-g/mL）。醌环似乎对于这种体外活性至关重要。
The cytotoxicity of a crude extract from Dactylospongia elegans stimulated a search for the active constituents. The structures and absolute stereochemistry are elucidated for four new. 9, 11, 18, 19. and thirteen previously described compounds, 3, 4, 6a. 7, 8, 10, 12 - 17, 21. These compounds were isolated from collections of D. elegans obtained from three different Indo-Pacific regions. Fiji. Papua New Guinea, and Thailand. This species appears to elaborate a broader range of the mixed biogenesis sesquiterpene-hydroquinone (-quinone) metabolites in comparison to those of other sponges or seaweeds. Three compounds, 4, 9, and 13. were potent (IC50's were less than 1-mu-g/mL). The quinone ring appears to be essential for this in vitro activity.