Functional diversities of two activity components of circadian rhythm in genetical splitting mice (CS strain)
Functional diversities of two activity components of circadian rhythm in genetical splitting mice (CS strain)
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DOI：
10.1007/s003590050322
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发表时间：
1999-03-01
期刊：
影响因子：
--
通讯作者：
Ebihara, S
中科院分区：
文献类型：
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作者：
Abe, H;Honma, S;Ebihara, S
近交系CS小鼠在运动活动的昼夜节律中表现出两个显著特征：（1）自由奔跑期间的大变化，（2）连续黑暗下的自发节律分裂。在分裂节律中，夜间成分的自由运行时间与早晨成分的活动时间呈正相关。15分钟的光脉冲的相移效果进行了检查的两个活动组件的分裂节奏。两种成分的光诱导相位响应量存在显著差异。在主观夜间后期的光脉冲引起的相位提前移位仅在早晨的组件，而在主观夜间早期的光脉冲引起的相位延迟移位仅在晚上的组件。这些结果表明CS小鼠昼夜运动节律中两个活动成分的功能性差异，并提示CS小鼠的昼夜节律系统由两个相互耦合的振荡器组成，这两个振荡器具有不同的昼夜节律周期和不同的光反应性。CS小鼠是一个有用的模型，以探讨在夜间啮齿动物的昼夜节律系统中的振荡器耦合的遗传背景。
CS mice, an inbred strain, showed two distinctive characteristics in the circadian rhythm of locomotor activity: (1) large variation in the freerunning period, and (2) spontaneous rhythm splitting under continuous darkness. In the splitting rhythm there was a positive correlation between the freerunning period of the evening component and the activity time of the morning component. The phase-shifting effect of a 15-min light pulse was examined on the two activity components of the splitting rhythm. There mere significant differences in the amount of light-induced phase response between the two components. A light pulse during the late subjective night induced a phase advance shift only in the morning component, while a light pulse during the early subjective night induced a phase delay shift only in the evening component. These results indicate functional diversities of the two activity components in the circadian locomotor rhythm of CS mice, and suggest that the circadian system in CS mice consists of two mutually coupled oscillators which have different circadian periods and different responsiveness to light. The CS mouse is a useful model to explore a genetic background of oscillator coupling in the circadian system of nocturnal rodents.