Calcium signaling in trypanosomatid parasites.
Calcium signaling in trypanosomatid parasites.
复制标题
锥形寄生虫中的钙信号传导。
DOI：
10.1016/j.ceca.2014.10.015
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发表时间：
2015-03
期刊：
影响因子：
4
通讯作者：
Huang G
中科院分区：
文献类型：
--
作者：
Docampo R;Huang G
钙离子 (Ca2+) 是锥虫动物中重要的第二信使，对其生存至关重要，尽管细胞内长期高 Ca2+ 水平会导致细胞死亡。与其他真核细胞一样，锥虫使用两种 Ca2+ 来源来产生信号：Ca2+ 从细胞内储存释放和 Ca2+ 穿过质膜进入。细胞内储存的 Ca2+ 释放由肌醇 1,4,5-三磷酸受体 (IP3R) 控制，该受体位于酸性钙体中，酸性细胞器是这些细胞中主要的 Ca2+ 储存库。质膜 Ca2+-ATP 酶控制胞质 Ca2+ 水平，许多泵和交换器负责 Ca2+ 从细胞内吸收和释放。锥虫基因组包含多种与 Ca2+ 结合的信号传导和调节蛋白，以及许多有待进一步表征的 Ca2+ 结合蛋白。锥虫的线粒体 Ca2+ 转运蛋白在细胞生物能的调节中发挥重要作用，鞭毛 Ca2+ 似乎在感知环境中发挥作用。在存在细胞内生命周期的锥虫中，Ca2+信号传导对于宿主细胞入侵非常重要。
Calcium ion (Ca2+) is an important second messenger in trypanosomatids and essential for their survival although prolonged high intracellular Ca2+ levels lead to cell death. As other eukaryotic cells, trypanosomes use two sources of Ca2+ for generating signals: Ca2+ release from intracellular stores and Ca2+ entry across the plasma membrane. Ca2+ release from intracellular stores is controlled by the inositol 1,4,5-trisphosphate receptor (IP3R) that is located in acidocalcisomes, acidic organelles that are the primary Ca2+ reservoir in these cells. A plasma membrane Ca2+-ATPase controls the cytosolic Ca2+ levels and a number of pumps and exchangers are responsible for Ca2+ uptake and release from intracellular compartments. The trypanosomatid genomes contain a wide variety of signaling and regulatory proteins that bind Ca2+ as well as many Ca2+-binding proteins that await further characterization. The mitochondrial Ca2+ transporters of trypanosomatids have an important role in the regulation of cell bioenergetics and flagellar Ca2+ appears to have roles in sensing the environment. In trypanosomatids in which an intracellular life cycle is present, Ca2+ signaling is important for host cell invasion.