IMPROVED SWEAT TEST METHOD FOR THE DIAGNOSIS OF CYSTIC-FIBROSIS
IMPROVED SWEAT TEST METHOD FOR THE DIAGNOSIS OF CYSTIC-FIBROSIS
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DOI：
10.1136/adc.59.10.919
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发表时间：
1984-01-01
影响因子：
5.2
通讯作者：
KUZEMKO, JA
中科院分区：
文献类型：
--
作者：
CARTER, EP;BARRETT, AD;KUZEMKO, JA
介绍了一种新的汗液渗透压和钠离子浓度测定技术。研究对象（82）（39名对照和43名囊性纤维化患者）。在81名受试者中获得足够量的汗液，并在73名受试者中分析汗液的渗透压和Na浓度。34个对照组的汗液渗透压和Na值分别为62 - 196 mmol/kg和9 - 72 mmol/l。39例囊性纤维化患者的渗透压值范围为220 - 416 mmol/kg，Na浓度范围为60 - 150 mmol/l。在8名50日龄以下婴儿中单独测定汗液渗透压[4名婴儿后来出现囊性纤维化的临床特征，4名婴儿疑似囊性纤维化，后来被排除]。这2组的汗液渗透压摩尔浓度值范围分别为255 - 345 mmol/kg和87 - 123 mmol/kg。收集汗液和测量渗透压摩尔浓度的简单性提供了优于先前描述的技术的明显优势。
A new technique of collecting sweat for measurement of osmolality and Na concentrations was described. Subjects (82) (39 controls and 43 patients with cystic fibrosis) were studied. Adequate amounts of sweat were obtained in 81 subjects and sweat was analyzed for both osmolality and Na concentrations in 73 subjects. The 34 controls gave sweat osmolality and Na values ranging from 62 to 196 mmol/kg and 9 to 72 mmol/l, respectively. The 39 cystic fibrosis patients gave osmolality values ranging from 220 to 416 mmol/kg and Na concentrations ranging from 60 to 150 mmol/l. Sweat osmolality alone was determined in 8 infants under 50 days of age [4 later developed the clinical features of cystic fibrosis and 4, in whom cystic fibrosis was suspected, were later excluded]. Sweat osmolality values in these 2 groups ranged from 255 to 345 mmol/kg and 87 to 123 mmol/kg, respectively. The simplicity of collecting sweat and the measurement of osmolality offer distinct advantages over techniques previously described.