Erythrocyte membrane fluidity in mild cognitive impairment and Alzheimer's disease patients
Erythrocyte membrane fluidity in mild cognitive impairment and Alzheimer's disease patients
复制标题
轻度认知功能障碍和阿尔茨海默病患者红细胞膜流动性的研究
DOI：
10.1016/j.exger.2019.110754
复制
发表时间：
2019-12-01
影响因子：
3.9
通讯作者：
Fiorini, Rosamaria
中科院分区：
文献类型：
--
作者：
Vignini, Arianna;Alia, Sonila;Fiorini, Rosamaria
阿尔茨海默病（AD）是痴呆症的最常见原因，占所有痴呆症病例的60-70%，并且是老龄化人口中发病率和死亡率的主要来源之一。最近的大多数文献关于血浆氧化应激和AD之间的关系，显示AD和轻度认知障碍（MCI）患者的脂质过氧化标记物显着高于对照组。在AD中发生的活性氧物质的产生增加也可能是红细胞膜氧化损伤的原因。由于红细胞膜作为一个可变的障碍，氧运输，其稳定性的变化可以诱导细胞缺氧和脑组织的氧合。本研究测定了正常对照组、轻度认知功能障碍（MCI）和阿尔茨海默病（AD）患者的血浆氧自由基吸收能力（ORAC）和红细胞膜流动性。此外，红细胞膜乙酰胆碱酯酶（AchE）的活性已在控制和AD患者进行了测量。血浆ORAC显着降低MCI和AD受试者相对于对照组，而红细胞膜流动性的降低已被观察到只有在MCI患者。对照组与AD患者红细胞AchE活性无显著性差异。
Alzheimer's disease (AD) is the most common cause of dementia accounting for 60-70% of all demented cases and one of the leading sources of morbidity and mortality in the aging population. Most of the recent literature regards the relationship between plasma oxidative stress and AD, showing that markers of lipid peroxidation are significantly higher in AD and Mild Cognitive Impairment (MCI) patients with respect to control subjects. The increased generation of reactive oxygen species that occurs in AD may be also responsible for oxidative injury to erythrocyte membranes. Since erythrocyte membrane serves as a variable barrier to oxygen transport, changes in its stability can induce cellular hypoxia and the consequence brain tissue oxygenation. In this study, plasma oxygen radical absorbance capacity (ORAC) and erythrocyte membrane fluidity have been evaluated in control, MCI and AD patients. Moreover erythrocyte membrane acetylcholinesterase (AchE) activity has been measured in control and AD patients. Plasma ORAC significantly decreased in MCI and AD subjects with respect to the controls, while a decrease in erythrocyte membrane fluidity has been observed only in MCI patients. No significant differences were detected in erythrocyte AchE activity between control subjects and AD patients.