Parents' Attitudes Toward Pediatric Genetic Testing for Common Disease Risk
Parents' Attitudes Toward Pediatric Genetic Testing for Common Disease Risk
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DOI：
10.1542/peds.2010-0938
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发表时间：
2011-05-01
期刊：
影响因子：
8
通讯作者：
McBride, Colleen M.
中科院分区：
文献类型：
--
作者：
Tercyak, Kenneth P.;Alford, Sharon Hensley;McBride, Colleen M.
目的：描述父母对常见成人发病健康状况的儿科基因检测的态度，并确定这些态度背后的因素。参与者和方法：父母（n = 219）参加了一个大型的，集体实践的健康计划，提供了一个“多重”基因测试的敏感性，8常见，成人发病的健康状况，并完成了一项在线调查，评估他们对测试的风险和好处的态度和信念，他们愿意考虑让他们的孩子进行测试，结果：父母认为儿科测试的好处超过其风险（积极的决策平衡），并适度感兴趣的儿科测试。与积极决策平衡相关的变量包括更有兴趣了解他们孩子的基因-健康关联，预期理解他们孩子的遗传健康风险的难度较小，以及对了解他们孩子的健康风险降低的积极情绪反应（校正R-2 = 0.33，P < .0001）。同样，与父母更愿意测试相关的变量是母亲（与做父亲相比），他们的孩子更容易感知疾病风险，更有兴趣了解他们孩子的基因-健康关系，预计了解他们孩子的遗传健康风险的难度较小，预计了解他们孩子的健康风险降低后会有更积极的情绪反应，结论：随着常见成人发病疾病的遗传易感性检测的普及，儿科医生应预测父母对检测儿童的兴趣，并做好准备，以促进对此类检测的知情决策。儿科2011;127：e1288-e1295
OBJECTIVE: To describe parents' attitudes toward pediatric genetic testing for common, adult-onset health conditions and to identify factors underlying these attitudes.PARTICIPANTS AND METHODS: Parents (n = 219) enrolled in a large, group-practice health plan were offered a "multiplex" genetic test for susceptibility to 8 common, adult-onset health conditions and completed an online survey assessing attitudes and beliefs about the risks and benefits of the test for their child, their willingness to consider having their child tested, and other psychosocial variables.RESULTS: Parents viewed the benefits of pediatric testing to outweigh its risks (positive decisional balance) and were moderately interested in pediatric testing. Variables associated with positive decisional balance included greater interest in knowing about gene-health associations in their child, anticipation of less difficulty understanding their child's genetic health risks, and more positive emotional reactions to learning about their child's decreased health risks (adjusted R-2 = 0.33, P < .0001). Similarly, variables associated with greater parental willingness to test were being a mother (versus being a father), greater perceived risk of diseases in their child, greater interest in knowing about gene-health relationships in their child, anticipating less difficulty learning about their child's genetic health risks, anticipating more positive emotional reactions to learning about their child's decreased health risks, and positive decisional balance (adjusted R-2 = 0.57, P < .0001).CONCLUSIONS: As genetic susceptibility testing for common, adult-onset health conditions proliferates, pediatricians should anticipate parents' interest in testing children and be prepared to facilitate informed decision making about such testing. Pediatrics 2011;127:e1288-e1295