Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks
Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks
复制标题
通过代谢网络比较分析探索线粒体进化和代谢组织原理
DOI：
10.1016/j.ygeno.2010.03.006
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发表时间：
2010-06-01
期刊：
影响因子：
4.4
通讯作者：
Li, Yi-Xue
中科院分区：
文献类型：
--
作者：
Chang, Xiao;Wang, Zhuo;Li, Yi-Xue
内共生学说认为线粒体基因组来源于一种类似α-蛋白细菌的内共生菌，这是从序列分析中得出的结论。我们重建了线粒体和22个近缘物种的代谢网络，并在酶含量和网络拓扑水平上研究了线粒体代谢的进化。我们基于网络比对和基序识别的系统发育结果首次从系统生物学的角度支持了内共生理论。研究发现，线粒体代谢网络比近缘物种紧密得多，可能与专门化细胞器氧化磷酸化的效率较高有关，并且该网络高度聚集在TCA循环周围。此外，线粒体代谢网络对这些模块表现出高度的功能特异性。这一工作为在网络水平上理解线粒体的进化，以及线粒体代谢网络的组织原理提供了新的思路。(C)2010 Elsevier Inc.保留所有权利。
The endosymbiotic theory proposed that mitochondrial genomes are derived from an alpha-proteobacterium-like endosymbiont, which was concluded from sequence analysis. We rebuilt the metabolic networks of mitochondria and 22 relative species, and studied the evolution of mitochondrial metabolism at the level of enzyme content and network topology. Our phylogenetic results based on network alignment and motif identification supported the endosymbiotic theory from the point of view of systems biology for the first time. It was found that the mitochondrial metabolic network were much more compact than the relative species, probably related to the higher efficiency of oxidative phosphorylation of the specialized organelle, and the network is highly clustered around the TCA cycle. Moreover, the mitochondrial metabolic network exhibited high functional specificity to the modules. This work provided insight to the understanding of mitochondria evolution, and the organization principle of mitochondrial metabolic network at the network level. (c) 2010 Elsevier Inc. All rights reserved.