Papillomavirus in healthy skin of Australian animals
Papillomavirus in healthy skin of Australian animals
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DOI：
10.1099/vir.0.82195-0
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发表时间：
2006-11-01
影响因子：
3.8
通讯作者：
McMillan, Nigel A. J.
中科院分区：
文献类型：
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作者：
Antonsson, Annika;McMillan, Nigel A. J.
乳头瘤病毒是一组普遍存在的病毒，经常在人类的正常皮肤以及一系列不同的脊椎动物中发现。在这项研究中，从54个物种的225只澳大利亚动物的健康皮肤采集的拭子样本进行了分析，以确定是否存在乳头状瘤病毒DNA与一般皮肤乳头状瘤病毒引物对FAP 59/FAP 64。从三种不同的动物物种中鉴定出总共五种推定的和潜在的新动物乳头瘤病毒类型。在一种单孔目动物和两种有袋类动物中检测到乳头瘤病毒：三种来自考拉，一种来自东部灰袋鼠和一种针鼹鼠。乳头瘤病毒在考拉、针鼹和灰袋鼠中的感染率分别为14%（10/72）、20%（1/5）和4%（1/23）。系统发育分析进行了假定考拉乳头瘤病毒类型，可以克隆，它出现在系统发育树作为一个新的假定乳头瘤病毒属。这些数据将乳头瘤病毒感染的物种范围扩大到最原始的哺乳动物：单孔目动物和有袋动物。
Papillomaviruses are a group of ubiquitous viruses that are often found in normal skin of humans, as well as a range of different vertebrates. In this study, swab samples collected from the healthy skin of 225 Australian animals from 54 species were analysed for the presence of papillomavirus DNA with the general skin papillomavirus primer pair FAP59/FAP64. A total of five putative and potential new animal papillomavirus types were identified from three different animal species. The papillomaviruses were detected in one monotreme and two marsupial species: three from koalas, and one each from an Eastern grey kangaroo and an echidna. The papillomavirus prevalence in the three species was 14% (10/72) in koalas, 20% (1/5) in echidnas and 4% (1/23) in Eastern grey kangaroos. Phylogenetic analysis was performed on the putative koala papillomavirus type that could be cloned and it appears in the phylogenetic tree as a novel putative papillomavirus; genus. The data extend the range of species infected by papillomaviruses to the most primitive mammals: the monotremes and the marsupials.