Cystic Duct Carcinoma: A New Classification System and the Clinicopathological Features of 62 Patients.
Cystic Duct Carcinoma: A New Classification System and the Clinicopathological Features of 62 Patients.
复制标题
囊性管癌：新的分类系统和 62 例患者的临床病理特征
DOI：
10.3389/fonc.2021.696714
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发表时间：
2021
影响因子：
4.7
通讯作者：
Wang Y
中科院分区：
文献类型：
--
作者：
Nan L;Wang C;Dai Y;Wang J;Bo X;Zhang S;Zhang D;Liu H;Wang Y
胆囊癌是一种少见的胆道恶性肿瘤，发病率低，预后差。然而，该病的临床情况尚未明确，也没有开发出广泛适用的分类系统。62例CDC患者被纳入这项回顾性研究，并利用影像数据建立了新的分类系统。收集血液指标、放射学特征、病理特征、手术操作和总体生存数据。利用受试者工作特征(ROC)曲线评价新分类在预测可切除性方面的有效性，并采用K均值聚类和t分布随机邻居嵌入方法对结论进行验证。II型CDC患者的PT分期明显差于I型CDC患者。II型CDC患者更容易发生神经系统、血管系统和肝脏的远处转移和侵犯。II型CDC的可切除性明显差于I型CDC。II型CDC患者预后较差。ROC曲线分析和K-均值聚类分析表明，新的分类方法可以比现有的系统更好地对CDC患者进行分类。II型CDC患者的临床病理结果明显较差。新的分类系统在CDC患者分组方面有更好的准确性。
Cystic duct carcinoma (CDC) is a rare biliary malignancy with a low incidence and poor prognosis. However, the clinical landscape of the disease has not been clarified and no widely applicable classification system has been developed. Sixty-two patients with CDC were included in this retrospective study, and a new classification system was established using imaging data. Blood indices, radiological characteristics, pathological features, surgical procedures, and overall survival data were collected. The efficacy of the new classification in predicting resectability was evaluated using receiver operating characteristic (ROC) curves, and K-means clustering and t-distributed stochastic neighbor embedding were applied to verify the conclusion. The pT stage of patients with type II CDC was significantly worse than that of type I. Patients with type II CDC were more likely to experience distant metastasis and invasion of the nervous system, vascular system, and liver. The resectability of patients with type II CDC was significantly worse than that of patients with type I CDC. Patients with type II CDC had worse prognoses. ROC curve analysis and K-means clustering revealed that the new classification could better categorize patients with CDC than currently available systems. Patients with type II CDC have significantly worse clinicopathological outcomes. The new classification system has better accuracy in grouping patients with CDC.
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